SpectraCell Blog

Lipoprotein(a) and L-carnitine

Posted by SpectraCell Laboratories, Inc. on Thu, Feb 23, 2017 @ 02:24 PM

Lipoprotein(a) and L-carnitine

heart-health.gifMost people assume that standard cholesterol testing offers an adequate assessment of heart disease risk. If you, like many, have never heard of a lipoprotein profile test, you may be surprised to learn that this test assesses an important risk factor called Lipoprotein(a) or Lp(a) (“lipoprotein little a”). Influenced by genetics and strongly linked to heart disease and blood clotting problems, this risk factor unfortunately is not part of routine cholesterol tests or standard lipid panels. In fact, lipoprotein(a) is so strongly linked to heart disease, that it is one of the four lipid-related risk factors cited by the National Institutes of Health National Cholesterol Education Program (NCEP) as worthy of monitoring. Unfortunately, Lp(a) has been notoriously difficult to treat pharmacologically, as statins have shown little efficacy in lowering Lp(a) levels*.

In a recent double-blind, placebo-controlled trial, patients with elevated cholesterol and elevated Lp(a) were divided into two groups, each with 29 people: Group 1 received a statin only and Group 2 received the same statin plus 2 grams/day of L-carnitine, a supplement that plays a key role in fatty acid transport within cells. After 12 weeks, the group receiving only a statin showed about a 7% reduction in Lp(a), but the group receiving the L-carnitine in conjunction with the statin demonstrated over 19% reduction in Lp(a) levels. Authors suggest that co-administration of L-carnitine (whose primary function is fatty acid metabolism), may enhance efforts to lower Lp(a) compared to using a statin alone.

* See our blog post, “Shedding some light on cholesterol,” from January 19, 2017. 

For additional reading refer to the abstract L-Carnitine/Simvastatin Reduces Lipoprotein (a) Levels Compared with Simvastatin Monotherapy: A Randomized Double-Blind Placebo-Controlled Study published in the January 2017 issue of Lipids

 



 

Topics: Heart Disease, Heart Health, Lipoprotein(a), L-carnitine, Lower Lipoprotein(a), Standard Cholesterol Testing

CoQ10

Posted by Elissa Rodriguez on Wed, Oct 05, 2016 @ 03:58 PM

heart_apple.jpg

Why you should know about CoQ10 if you are taking a statin.

Most Americans have heard of statins, a group of drugs commonly prescribed to lower cholesterol levels.  But many people are not familiar with coenzyme Q10 (CoQ10), the micronutrient that is known to be depleted by most people who take statins. In fact, the original patent for statins (AKA “HMG-CoA reductase inhibitors”) acknowledged this as early as 1990; however, this is still not widely known today. CoQ10 (AKA ubiquinone because it is so ubiquitous in the body) is a substance that creates energy, the most fundamental of all cell functions. Tissues with a high energy requirement – heart, liver and muscles – require CoQ10 to work.  If these cells don’t have sufficient CoQ10, a person may eventually experience fatigue, muscular pains, or both. 

Do you know your CoQ10 status? Get your SpectraCell Micronutrient Test today!

GET TESTED 

Topics: micronutrients, Coenzyme Q10, Cardiovascular Health, Heart Disease, Nutrition, Heart Health, cardiovascular disease, statin, chronic, CoQ10, disease

What YOU didn't know about vitamin D

Posted by SpectraCell Laboratories, Inc. on Tue, Oct 29, 2013 @ 01:52 PM

vitamin D Vitamin D is a group of fat-soluble secosteroids responsible for enhancing intestinal absorption of calcium and phosphate. Vitamin D is the principle regulator of calcium homeostasis in the body.  It is essential for skeletal development and bone mineralization.  Inadequate exposure to sunlight contributes to vitamin D deficiency.  Vitamin D deficiency in adults can lead to osteoporosis.  Increasing evidence is accumulating that vitamin D may also contribute to antioxidant function by inhibiting lipid peroxidation.  The mechanism of the antioxidant effect is unknown.  Vitamin D is also needed for adequate blood levels of insulin and it also appears to demonstrate both immune enhancing and immunosuppressive effects.

 

Vitamin D Deficiency Symptoms:

  • Increased risk of death from cardiovascular disease
  • Cognitive impairment in older adults
  • Severe asthma in children
  • Cancer

Repletion Information:

Supplemental vitamin D is available as vitamin D2 or vitamin D3.  Vitamin D3 is considered to be the more biologically active form of the vitamin and at this time is the form most recommended for repletion. 

Download SpectraCell's Nutrition Correlation chart referencing the correlation between vitamin D with Estrogen and Testosterone and view our webinar on Clinical Implications of vitamin D and Calcium Deficiencies.

For more information on how to check your vitamin levels click here.

Topics: SpectraCell, Vitamin D, Heart Disease, deficiencies, health, Dr. Ron Grabowski, Heart Attack, micronutrient, vitamin deficiencies, Heart Health

Do the Prescriptions YOU take deplete your nutritional status?

Posted by SpectraCell Laboratories, Inc. on Wed, Jul 24, 2013 @ 03:34 PM

When a person takes prescription drugs or over the counter medication chances are that they can prescription depletions Page 1 resized 600 be affecting their nutrient levels. Below are some of the possible deficiencies that are correlated with each corresponding drug.

Antacids/Ulcer medications

  • vitamin B12 - Anemia, depression, tiredness, weakness, increased cardiovascular risk

  • Folic Acid - Birth defects, cervical dysplasia, anemia, heart disease, cancer risk

  • vitamin D - osteoporosis, muscle weakness, hearing loss

  • Calcium - Osteoporosis, heart and blood pressure irregularities, tooth decay

  • Iron - Anemia, weakness, fatigue, hair loss, brittle nails

  • Zinc - weak immunity, wound healing, sense of smell/taste, sexual dysfunction


Antibiotics

  • B vitamins, Vitamin K - short term depletion affects are minimal, but failure to re-inoculate the GI tract with beneficial bacteria (probiotics) often results in dysbiosis which causes gas, bloating, decreases digestion & absorption of nutrients, and also may lead to a variety of other health problems.

  • Calcium - osteoporosis, heart & blood pressure irregularities, tooth decay

  • magnesium - cardiovascular problems, asthma, osteoporosis, cramps, PMS

  • Iron - slow wound healing, fatigue, anemia

  • vitamin B6 - depression, sleep disturbance, increased cardiovascular disease risk

  • zinc - weak immunity, wound healing, sense of smell/taste, sexual dysfunction


Cholesterol drugs

  • Coenzyme Q10 - Various cardiovascular problems, weak immune system, low energy


Female Hormones

  • Vitamin B6 - depression, sleep disturbance, increased cardiovascular disease risk

  • Folic acid - birth defects, cervical dysplasia, anemia, cardiovascular disease

  • vitamin B1 - depression, irritability, memory loss, muscle weakness, edema

  • vitamin B2 - problems with skin, eyes, mucous membranes and nerves

  • vitamin B6 - depression, sleep disturbances, increased cardiovascular disease risk

  • vitamin B12 - anemia, depression, tiredness, weakness, increased cardiovascular risk

  • vitamin C - lowered immune system, easy bruising, poor wound healing

  • magnesium - cardiovascular problems, asthma, osteoporosis, cramps, PMS

  • selenium - lower immunity, reduced antioxidant protection'

  • zinc - weak immunity, wound healing, sense of smell/taste, sexual dysfunction


Anti-Inflammatories

  • calcium - osteoporosis, heart and blood pressure irregularities, tooth decay

  • vitamin D - osteoporosis, muscle weakness, hearing loss

  • magnesium - cardiovascular problems, asthma, osteoporosis, cramps, PMS

  • zinc - weak immunity, wound healing, sense of smell/taste, sexual dysfunction

  • vitamin C - lowered immunity, easy bruising, poor wound healing

  • vitamin B6 - depression, sleep disturbances,increased cardiovascular disease risk

  • vitamin B12 - anemia, depressioon, tiredness, weakness, increased cardiovascular risk

  • Folic Acid - birth defects, cervical dysplasia, anemia, cardiovascular disease

  • Selenium - lower immunity, reduced antioxidant protection

  • chromium - elevated blood sugar, cholesterol & triglycerides, diabetes risk

  • vitamin B5 - fatigue, listlessness, and possible problems with skin, liver and nerves

For a complete list of drugs and their correlating deficiencies click here

If you would like to check your nutrient levels click here

Topics: SpectraCell, micronutrients, Coenzyme Q10, Antidepressants, Cancer, autoimmune diseases, zinc, Vitamin D, Carnitine, Magnesium, Vitamin C, Vitamin E, Vitamin B6, B Vitamins, Folic Acid, Antioxidants, Fibromyalgia, Cholesterol, Cardiovascular Health, Heart Disease, Vitamin K, Vitamin B12, Chronic Disease, diabetes, immune system, E-zinc, Vitamins, Calcium, Fertility, PMS, deficiencies, chronic fatigue and nutrition, health, Inflammatory Bowel Disease, Depression, Diet, Digestion, Stress, Vitamin B1, micronutrient test, Inflammation, Vitamin B5, High Blood Pressure, Vitamin B2, Iron, Nutritional Deficiency, Cancer Prevention, Heart Health, Gastrointestinal Tract, Hypothyroidism, Allergies, Wound Healing, Vitamin B3, Antihistamines, cardiovascular disease, Nutrient, hypertension, Women's Health

Why Test YOUR Micronutrient Levels & MTHFR?

Posted by SpectraCell Laboratories, Inc. on Wed, Jul 10, 2013 @ 01:49 PM

New Grid 2013


Why is an MTHFR test important?

Determining your MTHFR genotype gives you valuable information about your body's ability to methylate.  Methylation is a crucial part of cell processes and reduced function has been linked to numerous medical conditions including neurological and cardiovascular disorders, mental dysfunctions and diabetes.  The old paradigm that we are simply at the mercy of our genes is now challenged by a new age of truly individualized healthcare.  Get vital knowledge for your personalized healthcare solutions today.

What role does nutrition play in this function?

Nutrition plays a substantial role in methylation pathways, and SpectraCell's Micronutrient testing can give you an accurate stats of 33 vitamins, minerals and amino acids.  You may be able to compensate for your body's inability to methylate efficiently through targeted repletion, and micronutrient testing will provide assessment of nutritional deficiencies.  The test also allows you to identify deficiencies in other micronutrients that can be contributing toward the development and/or progression of chronic disease and keep you from feeling your best.

SpectraCell Laboratories is combining the Micronutrient Testing and MTHFR Genotyping as a special package promotion.  To find out more CLICK HERE!

Topics: SpectraCell, micronutrients, micronutrient testing, Autoimmunity, cancer cells, autoimmune diseases, telomere length, Telomere testing, telomerase, B Vitamins, Antioxidants, Cardiovascular Health, MTHFR Genotyping, Genotyping, Heart Disease, vitamin, nutrition testing, supplements, Chronic Disease, diabetes, immune system, expecting mothers, early pregnancy, E-zinc, breast cancer, telomere, Elderly, Dr. Ron Grabowski, Minerals, micronutrient test, Nutritional Deficiency, Cancer Prevention, Heart Health, Gastrointestinal Tract, Hormones, telomere and cancer, Spectrox, Energy, Methylation, Estrogen, Immunidex, eczema and nutrition, Alzheimers, Free Radicals, Genetics, Dr. Eva Cwynar, Women's Health

Studies Show How Micronutrients can Help

Posted by SpectraCell Laboratories, Inc. on Thu, Apr 11, 2013 @ 03:04 PM

Vitamin D protects telomeres: a randomized, controlled trialTelomeres

Telomerase activity was measured before and after 37 people were given either placebo or about 2000IU of oral vitamin D supplements per day for 16 weeks.  Serum vitamin D levels for those taking the supplement increased almost 200%.  The telomerase activity increased over 19% as well, while the telomerase activity of those on placebo did not change. (International Journal of Obesity, June 2012)

LINK to ABSTRACT Increased telomerase activity and vitamin D supplementation in overweight African Americans.
LINK to FLYER ON NUTRIENT INTERACTIONS WITH TELOMERES

Vitamin C helps antidepressant drug work better
Vitamin C In this randomized, double-blind, placebo controlled trial, a group of patients with major depressive disorder (n=12) were given fluoxetine plus 1000mg of vitamin C daily and compared to a group (n=12) that were given fluoxetine plus placebo.  After six months, those receiving vitamin C in conjunction with fluoxetine showed a significant decrease in symptoms when evaluated using three different standardized depression rating systems compared to the placebo group. (Nutrition Journal, March 2013)

LINK to ABSTRACT Efficacy of vitamin C as an adjunct to fluoxetine therapy in pediatric major depressive disorder: a randomized, double-blind, placebo-controlled pilot study.
LINK to FREE FULL TEXT
LINK to FLYER ON NUTRIENT INTERACTIONS IN DEPRESSION

Serine improves ADHD symptoms
serine resized 600In this randomized, double-blind trial, 36 children diagnosed with ADHD received either 200mg of phosphatidylserine or placebo daily for two months.  Those receiving phosphatidylserine showed improved memory, attention and control of impulses compared to placebo.  Serine’s key role in psychiatric and neurological health has been gaining attention from studies such as this.  The authors concluded that phosphatidylserine “may be a safe and natural nutritional strategy for improving mental performance.”
(Journal of Human Nutrition and Dietetics, March 2013)

LINK to ABSTRACT The effect of phosphatidylserine administration on memory and symptoms of attention-deficit hyperactivity disorder: a randomised, double-blind, placebo-controlled clinical trial.
LINK to FLYER ON NUTRIENT INTERACTIONS IN ADHD

Are micronutrients underrated when it comes to pregnancy chances in assisted reproduction?
pregnancy resized 600Several recent studies are suggesting that micronutrient status prior to and during pregnancy should get more attention.  One study showed that low blood values of B vitamins and high homocysteine in mid pregnancy reduced fetal growth rates.  Another study showed that low homocysteine, determined by B vitamin status, was linked to a better chance of pregnancy in women undergoing assisted reproduction.  Yet another study showed that subfertile women undergoing ovulation induction who were taking a multi-micronutrient vitamin were more likely to get pregnant than women who took only a folic acid supplement.  Finally, a recently published review demonstrates how increasing a woman’s ability to fight oxidative stress increases her chances of successful pregnancy via assisted reproduction.
(Maternal of Child Nutrition, April 2013)
(Journal of Assisted Reproduction and Genetics, April 2012)
(Reproductive Biomedicine Online, January 2012)
(Reproductive Biology and Endocrinology, June 2012)

LINK to ABSTRACT Folate, Vitamin B12, Vitamin B6 and homocysteine: impact on pregnancy outcome.
LINK to ABSTRACT
The association between homocysteine in the follicular fluid with embryo quality and pregnancy rate in assisted reproductive techniques.
LINK to ABSTRACT Prospective randomized trial of multiple micronutrients in subfertile women undergoing ovulation induction: a pilot study.
LINK to ABSTRACT The effects of oxidative stress on female reproduction: a review.
LINK to FREE FULL TEXT
LINK to FLYER ON NUTRIENT INTERACTIONS IN FEMALE FERTILITY

Study sheds light on CoQ10’s role in healthy spermsperm resized 600
Sixty infertile men were given 200mg of CoQ10 or placebo for 3 months.  CoQ10 lowered oxidative stress in semen (measured by isoprostanes and superoxide dismutase activity) and improved sperm function significantly. (Andrologia, January 2013)

LINK to ABSTRACT Effect of Coenzyme Q10 supplementation on antioxidant enzymes activity and oxidative stress of seminal plasma: a double-blind randomised clinical trial.

 

For more information on micronutrients and telomeres CLICK HERE

 

Topics: SpectraCell, serine, micronutrients, Coenzyme Q10, Antidepressants, Vitamin D, Vitamin C, Telomere testing, telomere, deficiency, micronutrient test, ADHD, Nutritional Deficiency, Heart Health, Nutrient, telomere test, Hormones, Aging, Reproductive Health, infertility, Testosterone, Women's Health

Clinical Applications of MTHFR Genomic Testing

Posted by SpectraCell Laboratories, Inc. on Tue, Jan 22, 2013 @ 03:50 PM

Clinical Applications of MTHFR Genomic Testing webinar presented by Dr. Bridget Briggs
 
What you learned:  Dr. Briggs, MTHFR
  • Methylation processes in the body. 
  • The function of MTHFR and the common polymorphisms found in 40% of Americans
  • The links between the common polymorphisms in MTHFR and risks involving cardiovascular disease, thromboembolic disease, irritable bowel, depression, memory agility, autoimmunity, poor detoxification, infertility, PMS, insomnia and many other disorders. 
  • Treatment for patients with common polymorphisms including L-5 MTHF, Methylcobalamin, B6, Trimethylglycine, inositol, and other key nutrients.

  • Case Study Review

Clinical Applications of MTHFR Genomic Testing Webinar

 

Topics: SpectraCell, Autoimmunity, cancer cells, autoimmune diseases, Telomere testing, B Vitamins, Fibromyalgia, ApoE Genotyping, Cardiovascular Health, diagnostic tools, MTHFR Genotyping, Genotyping, Multivitamins, Chronic Disease, immune system, breast cancer, deficiencies, Elderly, chronic fatigue and nutrition, health, Case Study, Inflammatory Bowel Disease, degenerative illness, Cancer Prevention, Heart Health, Gastrointestinal Tract, cardiovascular disease, Energy, Methylation, Immunidex, Immunity, eczema and nutrition, Genetics, Bowel Disease, Controversy, Dr. Bridget Briggs, Women's Health

The Importance of Vitamins

Posted by SpectraCell Laboratories, Inc. on Fri, Jan 04, 2013 @ 01:12 PM

New study says multivitamins just don’t cut it when it comes to preventing heart diseaseVitamins, multi-vitamins

In the landmark Physician’s Health Study II, authors concluded that taking a multivitamin for over a decade did nothing to prevent cardiovascular events such as myocardial infarction or stroke. The study monitored 14,641 male doctors for over eleven years who took either a daily multivitamin or placebo and no differences in cardiovascular events or mortality was found between the two groups.  Since evidence linking deficiencies to heart disease is strong (see vitamin D study below on 45,000 patients), some conclude that a multivitamin is simply not effective in correcting deficiencies and that targeted supplementation for the individual is a better approach. (Journal of the American Medical Association, November 2012)
(American Journal of Cardiology, October 2010)

Link to ABSTRACT Multivitamins in the prevention of cardiovascular disease in men: the Physicians' Health Study II randomized controlled trial.

Link to ABSTRACT Relation of vitamin D deficiency to cardiovascular risk factors, disease status, and incident events in a general healthcare population.

Vitamin C reduces fatigue and perception of effort after exercise

Vitamins, vitamin cIn this interesting study on twenty obese adults, each were given either 500 mg of vitamin C or placebo daily for four weeks.  Their diet was strictly controlled for vitamin C content and their heart rates and fatigue scores as well as subjective perceptions of exertion were measured after exercise.  Those taking vitamin C had lower fatigue scores and those on placebo had higher fatigue scores. Heart rates and “ratings of perceived exertion” were also improved in the vitamin C group. (Nutrition, January 2013)   

Link to ABSTRACT Vitamin C status and perception of effort during exercise in obese adults adhering to a calorie-reduced diet.

For more articles and information, click here for the complete library on clinical updates.

Topics: Coenzyme Q10, zinc, Vitamin D, Vitamin C, Vitamin E, Vitamin A, Vitamin B6, B Vitamins, Folic Acid, Copper, diagnostic tools, Heart Disease, vitamin, Vitamin K, Vitamin B12, supplements, Multivitamins, E-zinc, Vitamins, deficiencies, Heart Attack, Diet, Minerals, Vitamin B1, micronutrient test, Vitamin B5, High Blood Pressure, Vitamin B2, Heart Health, Vitamin B3, Aging, Stroke