SpectraCell's Educational webinar series hosted every month addresses how various diagnostic tools can aide in improving patient outcomes. To view our complete webinar library, please be sure to visit by clicking here.
One of our most recent webinar presentations is highlighted below. The presentation gives the viewer a detailed look into understanding methylation processes and key components that may or may not affect estrogen metabolism presented by Dr. Karan Y. Baucom an expert in the field.
Estrogen Metabolism and its Clinical Applications
Presented by Karan Y. Baucom, MD
- Overview of the methylation process and its effects on clinical conditions
- Understand key components of the biochemical pathways affecting methylation and estrogen metabolism
- The role of nutrition in the methylation process and estrogen metabolism
- Case Study Review
Click on the image below to view SpectraCell's webinar on "Estrogen Metabolism and its Clinical Applications."
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SpectraCell is at the forefront of providing a variety of resources to further expand our followers' knowledge in the area of integrative health. To learn more about the tests SpectraCell offers, please visit www.spectracell.com and to register for future webinars please check www.spectracell.com/webinars.
Recent finding suggests testosterone therapy in men not harmful to prostate
In a recently published study, 1023 hypogonadal men who received testosterone therapy were monitored for an average of 5 years for prostate cancer. The authors concluded that “testosterone therapy in hypogonadal men does not increase the risk of prostate cancer” although the authors did explicitly note that there was not control group in this study of men not taking testosterone.
Similar conclusions were reported in a different review of a testosterone replacement therapy in men, although the effect of testosterone on cardiovascular disease and events was much less clear. Whether or not to treat men with testosterone remains equivocal, as highlighted in the clinical decisions case study listed below.
(Journal of Urology, January 2015)
(Therapeutic Advances in Drug Safety, October 2014)
(New England Journal of Medicine, November 2014)
LINK to ABSTRACT Incidence of prostate cancer in hypogonadal men receiving testosterone therapy: observations from 5-year median followup of 3 registries.
LINK to ABSTRACT Adverse effects of testosterone replacement therapy: an update on the evidence and controversy. LINK to FREE FULL TEXT
LINK to CASE STUDY Clinical decisions. Testosterone-replacement therapy.
For more information or to get tested, please visit www.spectracell.com
SpectraCell is expanding their hormone and thyroid test menu.
Like nutrients, hormones influence all aspects of health and disease - mood, sleep, metabolism, immunity, heart health and appearance. An imbalance of one hormone can initiate a cascade of events that alters other hormones, so a comprehensive look at hormone status is key. Thyroid hormones directly regulate every cell in our body as most basic functions like metabolism, emotions and thinking. The below components have been added to our already established hormone and thyroid test.
Estrone sulfate (E1) – Included in our male and female hormone profiles
This estrogen has very strong tissue proliferative effects and may be linked to estrogen dominant conditions like fibrocystic breasts, endometriosis and uterine fibroids. It will create either dangerous or beneficial metabolites, depending on a person's nutritional status.
Estriol, unconjugated (E3) – Included in our female hormone profile
Estriol is a weak estrogen that is very high during pregnancy, but also plays an important role in non-pregnant women by opposing the growth of cancer cells promoted by the stronger estrogens E1 and E2. Estriol is also known to alleviate menopausal symptoms such as hot flashes or urinary incontinence.
Reverse Triiodothyronine (Reverse T3) – Must be ordered individually
As the name implies, Reverse T3 opposes the biological action of T3. It slows metabolism and renders T3 in the body biologically inactive. The rate of rT3 production relative to T3 will increase in times of stress (high cortisol) and in the presence of nutrient deficiencies, inflammation or certain medications.
To learn more about how to get tested, please visit our GET TESTED page HERE.
There are currently about 25 million Americans diagnosed with some sort of thyroid disorder. Thyroid disorders tend to be more prominent in women and the probability of a thyroid disorder occurring is four times more likely in women than in men.
What exactly is the thyroid?
- A butterfly shaped gland in the neck
- Makes T3 , T4 and calcitonin (calcium regulating hormone)
Symptoms of a Thyroid disorder
- Weight gain, even though you are not eating more food.
- Increased sensitivity to cold.
- Muscle weakness.
- Joint or muscle pain.
- Fatigue (feeling very tired)
- Pale dry skin.
Watch SpectraCell's webinar on
Integrative Diagnostics for Managing the Thyroid HERE
Micronutrients profoundly affect hormonal health. It is difficult to achieve hormonal balance if micronutrient status is inadequate, and like nutrients, hormones affect cellular metabolism, energy production, detoxification efficiency and mental health so balance is Key.
Like nutrients, hormones influence all aspects of health and disease - mood, sleep, metabolism, immunity, heart health and appearance. An imbalance of one hormone can initiate a cascade of events that alters other hormones.
- Fatigue & Energy Levels
- Cardiovascular health (Blood pressure, clotting, lipids)
- Neurology (migraines, sleep, pain)
- Mental Health (depression, anxiety, cognitive function)
- Immunity (infections, autoimmune disease)
- Metabolism (blood sugar regulation, tissue repair)
- Bone density (Osteoporosis)
- Physical appearance (skin, muscles, hair)
SpectraCell Laboratories offers comprehensive male and female hormone panels that reveal the overall state of hormonal balance in a patient.
A comprehensive look at your hormone status is key.
Vitamin A is a group of nutritionally unsaturated hydrocarbons. Different forms of the vitamin include retinol, retinoic acid, and carotenoids. Retinol is the most biologically active form of vitamin A and is synthesized by pro-vitamin A(beta-carotene). Vitamin A regulates cell proliferation, differentiation, immune function and apoptosis (cell death). This vitamin plays a vital role in night or low-light vision and color vision among many other common functions.
Symptoms of vitamin A deficiency - Impaired immune function; eye or skin problems; compromised cell growth and development; fat malabsorption; night blindness; zinc deficiency; insomnia.
Common conditions associated with vitamin A deficiency - Hormone balance, Immunidex, Insomnia, night blindness.
CASE STUDY highlights a common problem with a vitamin A deficiency. A 45 year old female with multiple conditions such as hypertension, insomnia and GERD, click here.
View our webinars Nutritional Considerations of Hormone Balance and Nutritional Considerations of Skin disorders, which references vitamin A deficiency among others in these conditions.
To check your micronutrient levels or to get started click here
Dr. Ron Grabowski,
mitral valve prolapse,
eczema and nutrition,
Why is an MTHFR test important?
Determining your MTHFR genotype gives you valuable information about your body's ability to methylate. Methylation is a crucial part of cell processes and reduced function has been linked to numerous medical conditions including neurological and cardiovascular disorders, mental dysfunctions and diabetes. The old paradigm that we are simply at the mercy of our genes is now challenged by a new age of truly individualized healthcare. Get vital knowledge for your personalized healthcare solutions today.
What role does nutrition play in this function?
Nutrition plays a substantial role in methylation pathways, and SpectraCell's Micronutrient testing can give you an accurate stats of 33 vitamins, minerals and amino acids. You may be able to compensate for your body's inability to methylate efficiently through targeted repletion, and micronutrient testing will provide assessment of nutritional deficiencies. The test also allows you to identify deficiencies in other micronutrients that can be contributing toward the development and/or progression of chronic disease and keep you from feeling your best.
SpectraCell Laboratories is combining the Micronutrient Testing and MTHFR Genotyping as a special package promotion. To find out more CLICK HERE!
Dr. Ron Grabowski,
telomere and cancer,
eczema and nutrition,
Dr. Eva Cwynar,
Vitamin D protects telomeres: a randomized, controlled trial
Telomerase activity was measured before and after 37 people were given either placebo or about 2000IU of oral vitamin D supplements per day for 16 weeks. Serum vitamin D levels for those taking the supplement increased almost 200%. The telomerase activity increased over 19% as well, while the telomerase activity of those on placebo did not change. (International Journal of Obesity, June 2012)
LINK to ABSTRACT Increased telomerase activity and vitamin D supplementation in overweight African Americans.
LINK to FLYER ON NUTRIENT INTERACTIONS WITH TELOMERES
Vitamin C helps antidepressant drug work better
In this randomized, double-blind, placebo controlled trial, a group of patients with major depressive disorder (n=12) were given fluoxetine plus 1000mg of vitamin C daily and compared to a group (n=12) that were given fluoxetine plus placebo. After six months, those receiving vitamin C in conjunction with fluoxetine showed a significant decrease in symptoms when evaluated using three different standardized depression rating systems compared to the placebo group. (Nutrition Journal, March 2013)
LINK to ABSTRACT Efficacy of vitamin C as an adjunct to fluoxetine therapy in pediatric major depressive disorder: a randomized, double-blind, placebo-controlled pilot study.
LINK to FREE FULL TEXT
LINK to FLYER ON NUTRIENT INTERACTIONS IN DEPRESSION
Serine improves ADHD symptoms
In this randomized, double-blind trial, 36 children diagnosed with ADHD received either 200mg of phosphatidylserine or placebo daily for two months. Those receiving phosphatidylserine showed improved memory, attention and control of impulses compared to placebo. Serine’s key role in psychiatric and neurological health has been gaining attention from studies such as this. The authors concluded that phosphatidylserine “may be a safe and natural nutritional strategy for improving mental performance.”
(Journal of Human Nutrition and Dietetics, March 2013)
LINK to ABSTRACT The effect of phosphatidylserine administration on memory and symptoms of attention-deficit hyperactivity disorder: a randomised, double-blind, placebo-controlled clinical trial.
LINK to FLYER ON NUTRIENT INTERACTIONS IN ADHD
Are micronutrients underrated when it comes to pregnancy chances in assisted reproduction?
Several recent studies are suggesting that micronutrient status prior to and during pregnancy should get more attention. One study showed that low blood values of B vitamins and high homocysteine in mid pregnancy reduced fetal growth rates. Another study showed that low homocysteine, determined by B vitamin status, was linked to a better chance of pregnancy in women undergoing assisted reproduction. Yet another study showed that subfertile women undergoing ovulation induction who were taking a multi-micronutrient vitamin were more likely to get pregnant than women who took only a folic acid supplement. Finally, a recently published review demonstrates how increasing a woman’s ability to fight oxidative stress increases her chances of successful pregnancy via assisted reproduction.
(Maternal of Child Nutrition, April 2013)
(Journal of Assisted Reproduction and Genetics, April 2012)
(Reproductive Biomedicine Online, January 2012)
(Reproductive Biology and Endocrinology, June 2012)
LINK to ABSTRACT Folate, Vitamin B12, Vitamin B6 and homocysteine: impact on pregnancy outcome.
LINK to ABSTRACT The association between homocysteine in the follicular fluid with embryo quality and pregnancy rate in assisted reproductive techniques.
LINK to ABSTRACT Prospective randomized trial of multiple micronutrients in subfertile women undergoing ovulation induction: a pilot study.
LINK to ABSTRACT The effects of oxidative stress on female reproduction: a review.
LINK to FREE FULL TEXT
LINK to FLYER ON NUTRIENT INTERACTIONS IN FEMALE FERTILITY
Study sheds light on CoQ10’s role in healthy sperm
Sixty infertile men were given 200mg of CoQ10 or placebo for 3 months. CoQ10 lowered oxidative stress in semen (measured by isoprostanes and superoxide dismutase activity) and improved sperm function significantly. (Andrologia, January 2013)
LINK to ABSTRACT Effect of Coenzyme Q10 supplementation on antioxidant enzymes activity and oxidative stress of seminal plasma: a double-blind randomised clinical trial.
For more information on micronutrients and telomeres CLICK HERE
Folate Deficiency reduces circulating testosterone; Evidence suggests testosterone may regulate folate metabolism.1,2,3
Vitamin B6 Regulates sex hormones; Vitamin B6 reduces prolactin which stimulates hypothalamus to increase testosterone; B6 also a cofactor for dopamine synthesis which influences testosterone levels.4,5,6,7
Vitamin D Actually a hormone, vitamin D regulates the synthesis of testosterone; Supplementation can significantly increase total, free and bioactive testosterone levels. 8,9,10,11,12
Vitamin K Deficiency reduces testosterone production because the rate-limiting enzyme for testosterone synthesis (Cyp11a) is vitamin K dependent. 13,14,15
Vitamin E Long term administration of some forms of vitamin E may reduce testosterone levels.16,17
Vitamin C Studies suggest it protects prostate from testosterone induced tumors.18,19,20
Carnitine Boosts dopamine, which is directly related to testosterone levels; May prevent testosterone decline after intense physical stress.21,22,23,24
Magnesium Makes testosterone more biologically active in the body; Raises free and total testosterone levels in men.25,26,27
Zinc Deficiency lowers testosterone levels; Inhibits prolactin secretion (testosterone
inhibiting hormone); Supplementation increases testosterone depending on baseline levels.28,29,30,31
Choline - Estrogen stimulates the breakdown of phosphatidylcholine (cell membrane) so those with low estrogen (postmenopausal women) require more choline; Detoxifies excess estrogen via methylation pathway.1,32,33
Folate - Deficiency reduces estrogen levels; Excess folate is linked to some types of estrogen-related breast cancer; Detoxifies excess estrogen via methylation pathway; Regulates estrogen’s effect on genes.1,2,3
Vitamin B6 - Protects genes from estrogen-induced damage thus lowering risk of hormone related cancers; Detoxifies excess estrogen via methylation pathway; Estrogen-based oral contraceptives cause B6 deficiency.4,5,6,7
Vitamin D - Regulates synthesis of estradiol and estrone; Enhances estrogen’s protective effect on bones.8,9,10
Vitamin C - Increases the most potent estrogen (estradiol) in women on hormone therapy; Lowers aromatase (enzyme that converts testosterone to estrogen) in ovaries.11.12.13
Vitamin K - Inhibits estrogen activity by binding to estrogen receptors; Lowers the ratio of estradiol (strong estrogen) to estrone (weaker estrogen).14,15
Vitamin E - Deficiency impairs estrogen detoxification pathway; Some forms of vitamin E inhibit estrogen action, especially in breast tissue; Low levels linked to higher estrogen.1,16,17
Vitamin A - Helps metabolize the biologically active estrogen (estradiol) to an inactive form (estrone).18,19
Calcium - Calcium-D-glucarate lowers estradiol levels; Helps breakdown estrogen in the liver and convert it to a less toxic form.1,20,21
Selenium - Estrogen levels affect how selenium is distributed to various tissues in the body.22,23
Magnesium - Cofactor for the enzyme that removes toxic forms of estrogen (catechol-O-methyltransferase); Estrogen alters magnesium levels throughout menstrual cycle.1,24,25,26
Zinc - Estrogen lowers risk of zinc deficiency; Zinc dependent proteins metabolize estrogen.26,27,28
Cysteine - Prevents oxidation of estrogen into a dangerous form that causes breast cancer.29,30,31
Click here to download your own Nutrient Correlation Wheel on Estrogen