SpectraCell Blog

Protecting Our Telomeres with Targeted Nutrition and Lifestyle Changes

Posted by SpectraCell Laboratories, Inc. on Fri, Aug 10, 2018 @ 03:29 PM

healthy girlMost people may not realize that there are two fundamental ways to protect telomeres:  (1) reduce the rate at which they shorten, also known as decreasing the telomere attrition rate and (2) to actually lengthen telomeres. Although it is commonly, albeit somewhat incorrectly, believed that once telomeres shorten they cannot get longer, recent evidence suggests otherwise. Common sense lifestyle choices can actually lengthen telomeres. This is comparable to reversing aging, versus simply slowing it down. For example, in a study started a decade ago, a group of men diagnosed with low-risk prostate cancer agreed to undergo comprehensive lifestyle changes for five years and be monitored during the course of the study. The lifestyle changes involved increased exercise, better nutrition, and better management of psychological stress - all choices within the reach of every person. After five years, telomere length improved. 

For those who want to take protection of their telomeres to the next level, targeted nutrition is key.  The effect micronutrients have on telomeres is profound.  For example:

CalciumRequired cofactor to prevent DNA replication errors.

FolateInfluences telomere length via DNA methylation.

Vitamin B3Extends lifespan of human cells in vitro; Slows telomere attrition rate by reducing reactive oxygen species in mitochondria.

B2, B6 and B12Crucial for proper DNA methylation.

CysteineStem cell treatment with N-acetyl cysteine corrects DNA damage in telomeres.

ZincImportant cofactor for DNA repair enzymes; key role in regulating inflammation.

CopperKey cofactor in the potent antioxidant superoxide dismutase that is known to protect telomeres.

MagnesiumInduced deficiency shortened telomeres in rat livers; Regulates chromosome separation in cell replication.

SeleniumIn vitro supplementation extended telomere length in liver cells; selenoproteins protect DNA.

GlutathioneInterference of glutathione dependent antioxidant defenses accelerates telomere erosion.

Vitamin CProtects DNA from oxidation. In vitro studies show it slows down age-related telomere shortening in human skin cells.

 Vitamin EEnhances DNA repair as well as removal of damaged DNA; Shown in vitro to restore telomere length on human cells.

Vitamin DPositively associated with telomere length due to its anti-inflammatory role.

ManganeseRequired cofactor in Mn superoxide dismutase, a deficiency in which decreases telomerase activity.

 

Discover how you can improve your telomere length with Micronutrient testing. 

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References:

Ornish et al. Increased telomerase activity and comprehensive lifestyle changes: a pilot study. Lancet Oncol. 2008;9:1048-57. 

Ornish et al. Effect of comprehensive lifestyle changes on telomerase activity and telomere length in men with biopsy-proven low-risk prostate cancer: 5-year follow-up of a descriptive pilot study. Lancet Oncol. 2013;14:1112-1120.

 

Topics: Micronutrients and Telomere Length, Cellular Age, Telomere Homeostatis, Age Management, Longer Telomeres

Vitamin D Linked to Longer Telomeres, Suggests Study

Posted by SpectraCell Laboratories, Inc. on Wed, May 31, 2017 @ 01:59 PM


Telomere.pngTelomeres – the protective DNA caps on every chromosome which shorten over time as a cell ages – have been correlated with chronic diseases in hundreds of studies.  A shorter telomere equates to an aging cell, and the cumulative effect of this may manifest as the degenerative diseases commonly associated with aging, including heart disease, cancer and dementia.  Low vitamin D has also been linked to several chronic diseases.  In this study, researchers sought to link the two – low vitamin D and shorter telomeres.  Telomere length was measured via PCR (polymerase chain reaction) on 4260 American adults ranging in age from 20 years old to over 60.  In the age group of 40-59 years, blood levels of vitamin D were correlated to telomere length.  In other words, higher vitamin D = longer telomeres. 

In a different study on participants from the same government-sponsored  survey (NHANES, National Health and Nutrition Examination Survey), 4347 American adults were evaluated for vitamin D levels and telomere length.  After adjusting for common demographic factors (age, race, education), higher vitamin D was linked to longer telomeres.  However, after adjusting for common physical factors (smoking, BMI, activity levels), no correlation was seen.  This suggests that vitamin D may very well be correlated with telomere length, but other factors play such a big role in healthy aging (such as not smoking or getting regular exercise) that these factors make the vitamin D-telomere connection less clear.

Serum 25-Hydroxyvitamin D Has a Modest Positive Association with Leukocyte Telomere Length in Middle-Aged US Adults. Link to ABSTRACT.

The association of telomere length and serum 25-hydroxyvitamin D levels in US adults: the National Health and Nutrition Examination Survey. Link to ABSTRACT. Link to FREE FULL TEXT. 



 

Topics: Vitamin D, telomere length, DNA, Anti-Aging, Age Management, Longer Telomeres, Degenerative Diseases