SpectraCell Blog

The Importance of Micronutrient Testing by Dr. Ron Grabowski, DC, RD

Posted by SpectraCell Laboratories, Inc. on Tue, Mar 21, 2017 @ 02:34 PM

 

 

Hear Dr. Grabowski’s take on the value of intracellular micronutrient testing, and how micronutrient deficiencies can reflect patterns seen in a variety of diseases.


 

Topics: micronutrient testing, Nutritional Deficiency, micronutrient deficiency

Do the Prescriptions YOU take deplete your nutritional status?

Posted by SpectraCell Laboratories, Inc. on Wed, Jul 24, 2013 @ 03:34 PM

When a person takes prescription drugs or over the counter medication chances are that they can prescription depletions Page 1 resized 600 be affecting their nutrient levels. Below are some of the possible deficiencies that are correlated with each corresponding drug.

Antacids/Ulcer medications

  • vitamin B12 - Anemia, depression, tiredness, weakness, increased cardiovascular risk

  • Folic Acid - Birth defects, cervical dysplasia, anemia, heart disease, cancer risk

  • vitamin D - osteoporosis, muscle weakness, hearing loss

  • Calcium - Osteoporosis, heart and blood pressure irregularities, tooth decay

  • Iron - Anemia, weakness, fatigue, hair loss, brittle nails

  • Zinc - weak immunity, wound healing, sense of smell/taste, sexual dysfunction


Antibiotics

  • B vitamins, Vitamin K - short term depletion affects are minimal, but failure to re-inoculate the GI tract with beneficial bacteria (probiotics) often results in dysbiosis which causes gas, bloating, decreases digestion & absorption of nutrients, and also may lead to a variety of other health problems.

  • Calcium - osteoporosis, heart & blood pressure irregularities, tooth decay

  • magnesium - cardiovascular problems, asthma, osteoporosis, cramps, PMS

  • Iron - slow wound healing, fatigue, anemia

  • vitamin B6 - depression, sleep disturbance, increased cardiovascular disease risk

  • zinc - weak immunity, wound healing, sense of smell/taste, sexual dysfunction


Cholesterol drugs

  • Coenzyme Q10 - Various cardiovascular problems, weak immune system, low energy


Female Hormones

  • Vitamin B6 - depression, sleep disturbance, increased cardiovascular disease risk

  • Folic acid - birth defects, cervical dysplasia, anemia, cardiovascular disease

  • vitamin B1 - depression, irritability, memory loss, muscle weakness, edema

  • vitamin B2 - problems with skin, eyes, mucous membranes and nerves

  • vitamin B6 - depression, sleep disturbances, increased cardiovascular disease risk

  • vitamin B12 - anemia, depression, tiredness, weakness, increased cardiovascular risk

  • vitamin C - lowered immune system, easy bruising, poor wound healing

  • magnesium - cardiovascular problems, asthma, osteoporosis, cramps, PMS

  • selenium - lower immunity, reduced antioxidant protection'

  • zinc - weak immunity, wound healing, sense of smell/taste, sexual dysfunction


Anti-Inflammatories

  • calcium - osteoporosis, heart and blood pressure irregularities, tooth decay

  • vitamin D - osteoporosis, muscle weakness, hearing loss

  • magnesium - cardiovascular problems, asthma, osteoporosis, cramps, PMS

  • zinc - weak immunity, wound healing, sense of smell/taste, sexual dysfunction

  • vitamin C - lowered immunity, easy bruising, poor wound healing

  • vitamin B6 - depression, sleep disturbances,increased cardiovascular disease risk

  • vitamin B12 - anemia, depressioon, tiredness, weakness, increased cardiovascular risk

  • Folic Acid - birth defects, cervical dysplasia, anemia, cardiovascular disease

  • Selenium - lower immunity, reduced antioxidant protection

  • chromium - elevated blood sugar, cholesterol & triglycerides, diabetes risk

  • vitamin B5 - fatigue, listlessness, and possible problems with skin, liver and nerves

For a complete list of drugs and their correlating deficiencies click here

If you would like to check your nutrient levels click here

Topics: SpectraCell, micronutrients, Coenzyme Q10, Antidepressants, Cancer, autoimmune diseases, zinc, Vitamin D, Carnitine, Magnesium, Vitamin C, Vitamin E, Vitamin B6, B Vitamins, Folic Acid, Antioxidants, Fibromyalgia, Cholesterol, Cardiovascular Health, Heart Disease, Vitamin K, Vitamin B12, Chronic Disease, diabetes, immune system, E-zinc, Vitamins, Calcium, Fertility, PMS, deficiencies, chronic fatigue and nutrition, health, Inflammatory Bowel Disease, Depression, Diet, Digestion, Stress, Vitamin B1, micronutrient test, Inflammation, Vitamin B5, High Blood Pressure, Vitamin B2, Iron, Nutritional Deficiency, Cancer Prevention, Heart Health, Gastrointestinal Tract, Hypothyroidism, Allergies, Wound Healing, Vitamin B3, Antihistamines, cardiovascular disease, Nutrient, hypertension, Women's Health

Why Test YOUR Micronutrient Levels & MTHFR?

Posted by SpectraCell Laboratories, Inc. on Wed, Jul 10, 2013 @ 01:49 PM

New Grid 2013


Why is an MTHFR test important?

Determining your MTHFR genotype gives you valuable information about your body's ability to methylate.  Methylation is a crucial part of cell processes and reduced function has been linked to numerous medical conditions including neurological and cardiovascular disorders, mental dysfunctions and diabetes.  The old paradigm that we are simply at the mercy of our genes is now challenged by a new age of truly individualized healthcare.  Get vital knowledge for your personalized healthcare solutions today.

What role does nutrition play in this function?

Nutrition plays a substantial role in methylation pathways, and SpectraCell's Micronutrient testing can give you an accurate stats of 33 vitamins, minerals and amino acids.  You may be able to compensate for your body's inability to methylate efficiently through targeted repletion, and micronutrient testing will provide assessment of nutritional deficiencies.  The test also allows you to identify deficiencies in other micronutrients that can be contributing toward the development and/or progression of chronic disease and keep you from feeling your best.

SpectraCell Laboratories is combining the Micronutrient Testing and MTHFR Genotyping as a special package promotion.  To find out more CLICK HERE!

Topics: SpectraCell, micronutrients, micronutrient testing, Autoimmunity, cancer cells, autoimmune diseases, telomere length, Telomere testing, telomerase, B Vitamins, Antioxidants, Cardiovascular Health, MTHFR Genotyping, Genotyping, Heart Disease, vitamin, nutrition testing, supplements, Chronic Disease, diabetes, immune system, expecting mothers, early pregnancy, E-zinc, breast cancer, telomere, Elderly, Dr. Ron Grabowski, Minerals, micronutrient test, Nutritional Deficiency, Cancer Prevention, Heart Health, Gastrointestinal Tract, Hormones, telomere and cancer, Spectrox, Energy, Methylation, Estrogen, Immunidex, eczema and nutrition, Alzheimers, Free Radicals, Genetics, Dr. Eva Cwynar, Women's Health

Studies Show How Micronutrients can Help

Posted by SpectraCell Laboratories, Inc. on Thu, Apr 11, 2013 @ 03:04 PM

Vitamin D protects telomeres: a randomized, controlled trialTelomeres

Telomerase activity was measured before and after 37 people were given either placebo or about 2000IU of oral vitamin D supplements per day for 16 weeks.  Serum vitamin D levels for those taking the supplement increased almost 200%.  The telomerase activity increased over 19% as well, while the telomerase activity of those on placebo did not change. (International Journal of Obesity, June 2012)

LINK to ABSTRACT Increased telomerase activity and vitamin D supplementation in overweight African Americans.
LINK to FLYER ON NUTRIENT INTERACTIONS WITH TELOMERES

Vitamin C helps antidepressant drug work better
Vitamin C In this randomized, double-blind, placebo controlled trial, a group of patients with major depressive disorder (n=12) were given fluoxetine plus 1000mg of vitamin C daily and compared to a group (n=12) that were given fluoxetine plus placebo.  After six months, those receiving vitamin C in conjunction with fluoxetine showed a significant decrease in symptoms when evaluated using three different standardized depression rating systems compared to the placebo group. (Nutrition Journal, March 2013)

LINK to ABSTRACT Efficacy of vitamin C as an adjunct to fluoxetine therapy in pediatric major depressive disorder: a randomized, double-blind, placebo-controlled pilot study.
LINK to FREE FULL TEXT
LINK to FLYER ON NUTRIENT INTERACTIONS IN DEPRESSION

Serine improves ADHD symptoms
serine resized 600In this randomized, double-blind trial, 36 children diagnosed with ADHD received either 200mg of phosphatidylserine or placebo daily for two months.  Those receiving phosphatidylserine showed improved memory, attention and control of impulses compared to placebo.  Serine’s key role in psychiatric and neurological health has been gaining attention from studies such as this.  The authors concluded that phosphatidylserine “may be a safe and natural nutritional strategy for improving mental performance.”
(Journal of Human Nutrition and Dietetics, March 2013)

LINK to ABSTRACT The effect of phosphatidylserine administration on memory and symptoms of attention-deficit hyperactivity disorder: a randomised, double-blind, placebo-controlled clinical trial.
LINK to FLYER ON NUTRIENT INTERACTIONS IN ADHD

Are micronutrients underrated when it comes to pregnancy chances in assisted reproduction?
pregnancy resized 600Several recent studies are suggesting that micronutrient status prior to and during pregnancy should get more attention.  One study showed that low blood values of B vitamins and high homocysteine in mid pregnancy reduced fetal growth rates.  Another study showed that low homocysteine, determined by B vitamin status, was linked to a better chance of pregnancy in women undergoing assisted reproduction.  Yet another study showed that subfertile women undergoing ovulation induction who were taking a multi-micronutrient vitamin were more likely to get pregnant than women who took only a folic acid supplement.  Finally, a recently published review demonstrates how increasing a woman’s ability to fight oxidative stress increases her chances of successful pregnancy via assisted reproduction.
(Maternal of Child Nutrition, April 2013)
(Journal of Assisted Reproduction and Genetics, April 2012)
(Reproductive Biomedicine Online, January 2012)
(Reproductive Biology and Endocrinology, June 2012)

LINK to ABSTRACT Folate, Vitamin B12, Vitamin B6 and homocysteine: impact on pregnancy outcome.
LINK to ABSTRACT
The association between homocysteine in the follicular fluid with embryo quality and pregnancy rate in assisted reproductive techniques.
LINK to ABSTRACT Prospective randomized trial of multiple micronutrients in subfertile women undergoing ovulation induction: a pilot study.
LINK to ABSTRACT The effects of oxidative stress on female reproduction: a review.
LINK to FREE FULL TEXT
LINK to FLYER ON NUTRIENT INTERACTIONS IN FEMALE FERTILITY

Study sheds light on CoQ10’s role in healthy spermsperm resized 600
Sixty infertile men were given 200mg of CoQ10 or placebo for 3 months.  CoQ10 lowered oxidative stress in semen (measured by isoprostanes and superoxide dismutase activity) and improved sperm function significantly. (Andrologia, January 2013)

LINK to ABSTRACT Effect of Coenzyme Q10 supplementation on antioxidant enzymes activity and oxidative stress of seminal plasma: a double-blind randomised clinical trial.

 

For more information on micronutrients and telomeres CLICK HERE

 

Topics: SpectraCell, serine, micronutrients, Coenzyme Q10, Antidepressants, Vitamin D, Vitamin C, Telomere testing, telomere, deficiency, micronutrient test, ADHD, Nutritional Deficiency, Heart Health, Nutrient, telomere test, Hormones, Aging, Reproductive Health, infertility, Testosterone, Women's Health

Vitamins, minerals and antioxidants can help!

Posted by SpectraCell Laboratories, Inc. on Thu, Jan 10, 2013 @ 01:20 PM

Is carnitine the answer for male infertility?male, infertility
A group of men (n=96) who had been diagnosed as infertile for at least 18 months were given the following nutritional formulation daily for four months: L-carnitine, acetyl-L-carnitine, fructose, citric acid, selenium, coenzyme Q10, zinc, vitamin C, vitamin B12 and folic acid (see abstract for exact dosages).  At the end of the study, sperm motility improved and 16 of the patients had achieved pregnancy.  The authors concluded that carnitine may be the key component of the supplement cocktail for improving sperm quality. (Italian Archives of Urology and Andrology, September 2012)

LINK to ABSTRACT Prospective open-label study on the efficacy and tolerability of a combination of nutritional supplements in primary infertile patients with idiopathic astenoteratozoospermia.

 

Vitamin D helps leg ulcers heal
In this double-blind, placebo controlled trial, 26 patients Vitamins, Vitamin Dwith leg ulcers were given either placebo or 50,000 IU vitamin D weekly for two months.  Leg ulcer size, blood levels of vitamin D and pain was measured before and after the two month trial.  In the vitamin D group, leg ulcers were reduced in size by 28% while the placebo group had only a 9% reduction in ulcer size. The authors stated “there was a trend toward better healing in those with vitamin D reposition.” (Journal of Brazilian College of Surgeons, October 2012)

LINK to ABSTRACT Vitamin D and skin repair: a prospective, double-blind and placebo controlled study in the healing of leg ulcers.
LINK to FREE FULL TEXT

 

Complexity of methylation reactions gains insightmethyl donor, nutrients
This review emphasizes how methyl donor nutrients such as choline, folic acid and methionine interact and how consumption (via supplement or food) of one can have sparing effect s on another – such as choline’s  sparing effect on methionine, for example. (Current Opinion in Clinical Nutrition and Metabolic Care, January 2013)

LINK to ABSTRACT The nutritional burden of methylation reactions.
LINK to FLYER on NUTRIENT INTERACTIONS in METHYLATION

For more journal articles by disease or nutrient please click here

 

Topics: SpectraCell, serine, micronutrients, Coenzyme Q10, Oleic Acid, Cysteine, autoimmune diseases, zinc, Vitamin D, Carnitine, Magnesium, Choline, Vitamin C, Vitamin E, Vitamin A, Selenium, Vitamin B6, B Vitamins, Folic Acid, Antioxidants, lipoprotein particle profile, Omega 3 Fatty Acid, diagnostic tools, vitamin, wellness, pregnancy, Serum, Vitamin K, Vitamin B12, supplements, Multivitamins, Nutrition, diabetes, immune system, E-zinc, N-acetylcysteine, DNA, Calcium, Fertility, Lipoic Acid, deficiencies, health, Case Study, Omega 3s, Depression, Glutamine, Minerals, Neurotransmitters, Stress, Vitamin B1, micronutrient test, Vitamin B5, Vitamin B2, Nutritional Deficiency, Vitamin B3, cardiovascular disease, Hormones, Reproductive Health, Chromium, Manganese, Muscle recovery, Erectile Dysfunction, infertility, Niacin, Prostate, Energy, Methylation, Carbohydrate Metabolism

Nutritional Deficiencies From Gluten Intolerance Worsens Autoimmunity

Posted by SpectraCell Laboratories, Inc. on Tue, Apr 03, 2012 @ 01:33 PM

Gluten IntoleranceGuest Blog by: Dr. Karl R.O.S. Johnson (D.C.)

If you have gluten intolerance like I do, you will have nutritional deficiencies. Nutritional deficiencies can lead to a wind up of the immune system thereby worsening autoimmunity and/or the devlopment of additional diseases. Often only iron, sodium and postasium levels are checked on routine blood tests.

You Owe It To Yourself To Get Your Nutrient Levels Checked

Many researchers feel this paltry testing is not comprehensive enough. Deficiencies of magnesium, B vitamins, vitamin C, vitamin K, omega 3 fats, amino acids, glutathione and other important micronutrients are typically lowered with gluten intolerance. This is mainily due initially to increased systemic inflammation, which places a greater burden on the enzymes of detoxification as well as other enzymes.

Chemical reactions in our body are catalyzed by enzymes, and vitamins and minerals are the co-factors that allow enzymes to work. Enzymes cannot function without adequate vitamins. Just as your car cannot work without the ignition key or tires, enzymes are stalled without minerals and vitamins.

Micronutrient TestingOne of the best ways to measure vitamins and other micronutrients is through SpectraCell Micronutrient Testing. This patented process resulted from 18 years of research at the University of Texas. The micronutrient test measures the biochemical function of vitamins, minerals, amino acids and antioxidants, providing me a powerful clinical assessment tool in order to help you recover your health.

Signs of nutritional deficiencies on standard blood tests are high homocysteine levels, high MCV and MCH as well as low iron, potassium, protein and albumin. All these and other markers of body malfunction are easier to detect using functional blood chemistry analysis and can be missed using the typical standard broad average lab ranges. Using functional blood chemistry analysis is an important and unique reason why I often am able to detect earlier signs of health deterioration. Check out the link to my functional blood chemistry analysis page for more information on this topic.

When your body enzymes are less able to function due to nutritional deficiencies, autoimmune processes get a chance to ramp up, leading to additional tissues to be targeted for attack.Human Body

Results: Coeliac patients showed a higher total plasma homocysteine level than the general population, indicative of a poor vitamin status. In accordance, the plasma levels of folate and pyridoxal 5″-phosphate (active form of vitamin B-6) were low in 37% and 20%, respectively, and accounted for 33% of the variation of the total plasma homocysteine level (P < 0.008). The mean daily intakes of folate and vitamin B-12, but not of vitamin B-6, were significantly lower in coeliac patients than in controls.
 
Conclusions: Half of the adult coeliac patients carefully treated with a gluten-free diet for several years showed signs of a poor vitamin status. This may have clinical implications considering the linkage between vitamin deficiency, elevated total plasma homocysteine levels and cardiovascular disease. The results may suggest that, when following up adults with coeliac disease, the vitamin status should be reviewed."[1]

The bottom line take away message is this: It's not enough to treat the symptoms of an illness or disease. The prudent clinician will look for underlying causes of imbalances in the patients' bodily processes, and work with the patient to regain balance. Often this is accomplished with dietary changes, specific supplementation, lifestyle changes and neurological rehabilitation.

Dr. Carl Johnson

Dr. Karl R.O.S. Johnson, D.C. - Help My Chronic Condition & Pain

For more information about our client Dr. Johnson, please visit his website or his blog. Or contact him at (586) 731-8840.

Contact our bloggers at spec1@spectracell.com.

Topics: micronutrient testing, Autoimmunity, Nutritional Deficiency, Dr. Karl R.O.S. Johnson, Celiac, Gluten Intolerance

Nutritional Considerations of ADHD & Autism

Posted by SpectraCell Laboratories, Inc. on Mon, Jan 23, 2012 @ 01:58 PM

ADHD & AutismADHD and AUTISM ON THE RISE
Recent years has seen an unprecedented rise in autism and attention deficit hyperactivity disorder (ADHD).

Although researchers speculate on the reason for this rise, many factors likely contribute, including more accurate diagnosis. However, overwhelming evidence suggests that nutritional deficiencies may be a contributing factor.

OMEGA-3 FATTY ACIDS ARE KEY
Our brain and nerves are composed mostly of fat. The most important of these are called omega-3 fatty acids and are found primarily in fish or fish oil supplements. Also called EPA and DHA, they are absolutely necessary for human health, and their concentration in the brain makes them key players in neurological disorders such as autism and ADHD. Brain and nerve growth throughout childhood is extraordinarily rapid, and the need for omega-3 fatty acids remains critical all the way through adolescence and into adulthood. Overwhelming evidence implicates deficiencies in omega-3 fatty acids for the rise in autism and ADHD. Research shows that children with low scores on behavioral assessment tests consistently have lower omega-3 fatty acids levels, and when supplemented with fish oils, the symptoms of ADHD in these children such as hyperactivity, impulsiveness, and inability to pay attention - dramatically improve.

Omega 3 & 6WHY MEASURE THE OMEGA-6 TO OMEGA-3 RATIO?
We are familiar with the expression that a child’s brain is like a sponge, ready to absorb information at an astounding rate. A truly appropriate analogy, it stems from the fact that our brains can actually create nerve pathways in response to new experiences and learning environments. Called “neuronal plasticity,” this phenomena is crucial for long-term memory and learning. Proper levels of the omega-3 fatty acid, DHA (docosahexaenoic acid), is important for membrane fluidity. The ratio of omega-6 fatty acids, which differ in structure and function, to omega-3 fatty acids affect neuronal plasticity as well. Scientists now agree that the ratio of omega-6 fats to omega-3 fats is as important as the actual levels, especially in autism and ADHD. A lower ratio is better and when this ratio is improved, symptoms of autism and ADHD can improve as well.

ZINC – THE MOOD MINERAL
Zinc deficiency is often implicated in ADHD because it is an important co-factor to several neurotransmitters, which directly affect mood and learning ability. Specifically, zinc affects the production of dopamine, a feel-good chemical in our brains that is needed for learning and certain emotions like motivation and pleasure. In fact, studies show that zinc levels correlate with anxiety and behavioral problems, as well as have a significant effect on information processing in boys with ADHD. Since zinc levels are much lower in autistic and ADHD individuals, children with ADHD show positive behavioral and cognitive results after zinc supplementation.In addition, zinc is essential for proper elimination of the toxic metal mercury from our brain tissue, which has also been linked to autism and ADHD.

Vitamins & AutismVITAMINS AND AUTISM
Low levels of vitamin D have been linked with autism and in some cases of severe deficiency, high-dose vitamin D therapy actually reversed some of the autistic behaviors. Some research even suggests that the nutritional status of the mother during gestation can affect behavior in children. One study confirmed that low folate status in pregnancy was associated with hyperactivity in children. Other studies show that persons who carried a common gene that predisposes them to folate and vitamin B12 deficiency (called the MTHFR gene) were more likely to suffer from ADHD. Supplementation with thiamine (vitamin B1) has shown clinical benefit to some autistic children. Specifically, a deficiency in vitamin B1 has been associated with delayed language development in childhood.When deficient, biotin (vitamin B7) can potentially cause neurological problems associated with autism since the brain is quite vulnerable to biotin deficiency.

MAGNESIUM AND VITAMIN B6 – A WINNING COMBINATION
Like most nutrients, magnesium and vitamin B6 work together in improving clinical symptoms of autism and ADHD.

When a group of autistic children were supplemented with magnesium and vitamin B6, 70% of the children showed improvement in social interaction and communication. Interestingly, when the supplements were stopped, the clinical symptoms reappeared. In another study, physical aggression and inattention improved after supplementation with magnesium and vitamin B6 for a few months.

NeurotransmittersTHE ROLE OF NEUROTRANSMITTERS
Neurotransmitters are tiny chemicals that transmit information from the outside world to various parts of our brains and from our brains to the rest of our bodies. Although neurotransmitters, such as choline, glutamine, asparagine and inositol may not be recognized as household names, they profoundly affect emotions, thinking and social behavior. For example, levels of glutamine and asparagine are lower in autistic children and some adults with ADHD.

AN AMINO ACID THAT IMPROVES CARNITINE – BEHAVIOR
Carnitine is an amino acid whose primary function is to transport fatty acids, including the ever-so-important omega-3 fatty acids into cells so they can be used for energy. In autistic individuals, carnitine levels are significantly reduced, which then affects the patient’s ability to use the fatty acids that are so critical to their learning and social development.
A recent study demonstrated that carnitine can reduce hyperactivity and improve social behavior in boys diagnosed with ADHD, and may actually represent a safe alternative to the use of stimulant drugs for the treatment of ADHD in children.

ADHD AND AUTISM – AN OXIDATIVE STRESS DISORDER?
Oxidative stress is a term used to describe damage to our cells that occurs on a daily basis throughout our bodies. Fortunately, our bodies have built-in defenses against the onslaught of internal and external toxins causing oxidative stress in our tissues. Interestingly, several studies show an increase in oxidative stress in both autism and ADHD, resulting in an impaired ability to eliminate toxins. Specifically, adults with ADHD have extremely low levels of some of the most powerful antioxidants in the body. One study linked damage in fatty tissue surrounding our cells to symptoms of autism and ADHD. Minerals such as selenium and copper, antioxidants such as cysteine and vitamin E and several other nutrients ensure the body’s powerful defense systems work optimally.

ADHD & AutismA MULTI-FACETED APPROACH
Since so many nutrients are needed to keep our amazingly complex brain and nervous system functioning properly, a comprehensive assessment of your nutritional status is key. In disorders like autism and ADHD, the potential improvement of symptoms when even a single deficiency is corrected can often be quite dramatic.

For more information, contact us at spec1@spectracell.com or call 800-227-5227.

Topics: zinc, Carnitine, Magnesium, Vitamin B6, Omega 3 Fatty Acid, vitamin, autism, Omega 3s, Neurotransmitters, ADHD, Nutritional Deficiency, Oxidative Stress, Omega 6

COMING SOON to a Lab Near You! Immunidex...

Posted by SpectraCell Laboratories, Inc. on Thu, Jan 19, 2012 @ 05:21 PM

SpectraCell ImmunidexWhat Does the Immunidex Measure?
A patient’s Immunidex score is one measurement to evaluate a person’s cell-mediated immune system performance. Specifically, it measures T-cell lymphocyte proliferation. Since immune function is a systemic measure of general health, a higher Immunidex score is generally desired since it means a person can respond efficiently not only to exogenous threats such as pathogens or allergens, but also to endogenous threats like tumors. The immune system, comprised of both cell-mediated (Th1) and humoral (Th2) components, when balanced and performing optimally, affords us critical protection and promotes health and wellness.

How is the Immunidex Performed?
A patient’s lymphocytes are isolated from whole blood and introduced to a protein that stimulates growth. The protein mitogen used to trigger mitosis, or cell division, is PHA (phytohemagglutinin), which stimulates T-lymphocytes to proliferate. The proliferative response is measured by the incorporation of radioactive thymidine into newly synthesized DNA. Your patient’s response is compared to responses of a reference population and results are reported to you as an Immunidex score.

Calcium DeficiencyWhat Affects the Immunidex Result?
Micronutrient deficiencies will undermine a person’s immune function, and thus lower the Immunidex. Since the highly complex immune system is dependent on the intracellular availability of vitamins, minerals and antioxidants, correcting specific micronutrient deficiencies typically raises the Immunidex and contributes to tangible clinical benefits, such as reduced infections and may assist in achieving Th1/Th2 balance.

How does the Immunidex correlate with antioxidant function?
In general, the higher the antioxidant score (Spectrox™), the higher the Immunidex score. Antioxidant function plays an important role in promoting optimal T-cell (lymphocyte) function. It is important to find out if a patient has deficiencies in specific antioxidant nutrients so they can supplement wisely. But it is also important to measure a total antioxidant function because the metabolic pathways in which antioxidants are involved are Spectroxhighly complex, sometimes redundant and often overlapping. Research confirms that taking excess antioxidants that are not needed (i.e. where no deficiency exists) can actually cause them to become pro-oxidants and decrease antioxidant function.

How is Immunidex related to aging?
As we age, our immune function typically decreases as seen in the figure below. Although many factors are involved in this complicated process of decline, the Immunidex is one of many relevant aging biomarkers since age diminishes the ability of a person’s lymphocytes to respond to challenges. The effects of both good and poor antioxidant function on the Immunidex is shown and emphasizes the importance of testing for antioxidant function (Spectrox™) and individual antioxidant deficiencies.

How do you order the Immunidex?
The Immunidex is part of SpectraCell’s Micronutrient Testing panel. There is no additional charge for this calculated test result. Ordering instructions are the same – same kit, same blood draw instructions.

Please contact your local representative for more details or email us at spec1@spectracell.com with any questions or comments!  Thank you.

Topics: Antioxidants, Nutritional Deficiency, Aging, Spectrox, Immunidex, Immunity