CLINICAL UPDATE – Nutritional status of mom has major implications for baby
Three recent studies emphasize the fallacy of the paradigm “baby gets what he needs at the expense of the mother.” In one study done in the Netherlands, researchers evaluated over 3200 mothers for blood folate levels and their children at three years of age for behavioural and emotional problems. Although the implications of low folate status of the mother on neurological development is well established, this study reported that low folate status of the mother is linked with a “higher risk of emotional problems in the offspring.” An unrelated study in India found a similar result with vitamin B12 and heart function. Cord blood of mothers was compared to the cardiac function of their babies. “Children born to mothers with a lower vitamin B12 status have a reduced cardiac sympathetic activity.” Finally, a review of studies done between 1999 and 2011 concluded that vitamin D deficiency of mom is linked to gestational diabetes. (American Journal of Clinical Nutrition, June 2012),(Maternal and Child Nutrition, May 2012),(Journal of Obstetric, Gynecologic and Neonatal Nursing, May 2012)
Link to Abstract Maternal folate status in early pregnancy and child emotional and behavioral problems: the Generation R Study.
Link to Abstract Low maternal vitamin B12 status during pregnancy is associated with reduced heart rate variability indices in young children.
Link to Abstract Maternal vitamin d status as a critical determinant in gestational diabetes.
CLINICAL UPDATE - E Zinc deficiency common in diabetics
Serum and intracellular levels were measured in 75 type I and II diabetics and compared to 75 age matched controls. Zinc levels were significantly lower in diabetic patients. Authors of the study reported that in vivo and in vitro studies indicate that zinc promotes insulin signalling and supplementation may be a potential treatment in zinc-deficient diabetics. (Journal of Nutritional Biochemistry, November 2012)
Link to Abstract Disturbed zinc homeostasis in diabetic patients by in vitro and in vivo analysis of insulinomimetic activity of zinc.
CLINICAL UPDATE – N-acetylcysteine lowers irritability in autistic kids
In this randomized clinical trial on 33 autistic children ages three to ten years old, a dose of 900mg N-acetylcysteine was given twice daily for 12 weeks. At each 4 week interval, a standardized test was given to measure irritability and behaviour on each child. After three months, those receiving the high-dose N-acetylcysteine had significant improvements on their irritability compared to the placebo group. (Biological Psychiatry, June 2012)
Link to Abstract A randomized controlled pilot trial of oral N-acetylcysteine in children with autism.
CLINICAL UPDATE – Vitamin D trial shows it can reduce body fat
In a double-blind, randomized, placebo-controlled trial, 77 people were given either 25mμg of vitamin D or placebo for 12 weeks. Researchers concluded that “supplementation with vitamin D3 caused a statistically significant decrease in body fat mass.” Specifically, the vitamin D group lost six pounds while the placebo group lost an average of only one pound. (Nutrition Journal, May 2012)
Link to Abstract A 12-week double-blind randomized clinical trial of vitamin D3 supplementation on body fat mass in healthy overweight and obese women.
CLINICAL UPDATE – Vitamin K reduces diabetes risk
Dietary intake of phylloquinone (a form of vitamin K) was assessed in over a thousand men and women. Those with increased intake of vitamin K hahave lower rates of diabetes. As a follow up to the study, the people who increased their dietary vitamin K during the follow-up had 51% reduced risk of diabetes. (American Journal of Clinical Nutrition, November 2012)
Link to Abstract Dietary phylloquinone intake and risk of type 2 diabetes in elderly subjects at high risk of cardiovascular disease.
CLINICAL UPDATE – Vitamin E kills cancer cells
The alpha, delta and gamma tocotrienol forms of vitamin E were evaluated on leukemic cancer cells. The delta tocotrienol form of vitamin E, which was the most potent in killing cancer cells, changed the DNA of the cancerous cells in such a way that it induced the cancerous cells to undergo apoptosis (cell death). (Microscopy and Microanalysis, June 2012)
Link to Abstract Delta- and gamma-tocotrienols induce classical ultrastructural apoptotic changes in human T lymphoblastic leukemic cells.
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