- Cysteine - reduces pain caused by systemic inflammation due to its potent antioxidant properties.
- Inositol - in animal studies, treatment with inositol induces antinociception (pain reduction).
- Oleic Acid - this fatty acid is a precursor of oleamide, an analgesic that affects neurotransmitters such as dopamine, serotonin, acetylcholine and GABA (gamma amino butyric acid), all of which play a role in pain signaling.
- Carnitine - deficiency of this amino acid may manifest as muscle weakness, pain (myalgia) or neuropathy. Supplementation reduces several types of chronic pain.
- Magnesium - lowers pain by blocking NMDA receptors in spinal cord; effective in reducing post-operative pain.
- Manganese - a cofactor for the potent antioxidant superoxide dismutase, which fights free radicals, a known source of pain.
- Copper - supplementation can relieve arthritic pain.
- Selenium - treatment with this mineral improves muscle pain in deficient patients.
- Zinc & Calcium - research suggests both play a role in the transmission of pain signals through nerves.
- Choline - activates specific receptors in brain and spine that lower acute pain.
- Vitamin B1, B2, B6, B12 - these produce a dose dependent decrease in various kinds of pain (heat, pressure, chemical); increases sensitivity to pain meds; their effect is likely mediated through serotonergic neurotransmitters.
- Vitamin D - deficiency often presents clinically as muscle or bone pain.
- Lipoic Acid - very effective treatment for neuropathic pain.
- Antioxidants - clinical trials show antioxidant therapy is an effective treatment for chronic pain
- Vitamin E - reduces neuropathic pain
- Vitamin C - can lower morphine consumption after surgery
- Coenzyme Q10 - relieves statin-induced myopathy.
Topics: Coenzyme Q10, Oleic Acid, Cysteine, zinc, Vitamin D, Carnitine, Magnesium, Choline, Vitamin C, Vitamin E, Selenium, Vitamin B6, Copper, Antioxidants, Pain, Vitamin B12, Calcium, Lipoic Acid, inositol, Vitamin B1, Vitamin B2, Manganese
Vitamin D & Musculoskeletal Pain
Vitamin D deficiency often presents clinically as musculoskeletal pain. Correcting this deficiency can improve bone and muscle pain dramatically in patients with fibromyalgia and the painful bone disease osteomalacia.
Coenzyme Q10 & Migraines, Myopathy
Supplementation with CoQ10 helps prevent migraine headaches, according to recent clinical trials. In addition, CoQ10 has been shown to relieve statin-induced myopathy by improving energy metabolism in muscle.
Carnitine & Myalgia, Neuropathy
This important amino acid facilitates the transport of fatty acids into cell mitochondria so they can be effectively used for energy. Studies suggest that a deficiency of carnitine manifests clinically as myalgia, muscle weakness or neuropathy. In fact, supplementation with carnitine has been shown to improve pain associated with chemotherapy-induced neuropathy, diabetic neuropathy, HIV-induced neuropathy, chronic fatigue syndrome and fibromyalgia.
Oleic Acid & Chronic Fatigue Syndrome
A recent study showed significant correlations between the severity of chronic fatigue syndrome and levels of oleic acid, a monounsaturated fatty acid used by the body in energy storage.
Magnesium & Post Operative Pain
Magnesium alters pain processing by blocking NMDA receptors in the spinal cord. In several recent studies, administration of magnesium reduced consumption of pain killers post-operatively. The analgesic effect has been seen in cardiac, orthopedic, thoracic and gynecological surgery. Low magnesium levels also contribute to headaches and correlate strongly with the frequency of chest pain. Its antinociceptive effect is promising.
Choline & Acute Pain
The activation of specific receptors by choline reduces acute inflammatory pain in mice, suggesting that administration of choline may help reduce the use of medication for inflammatory pain.
Alpha Lipoic Acid & Diabetic Neuropathy
Several clinical trials have documented the beneficial use of alpha-lipoic acid in the treatment of pain from diabetic polyneuropathy.
B Vitamins & Neuropathic Pain
A recent study suggests clinical usefulness of vitamins B1, B6 and B12 in the treatment of neuropathic painful conditions following injury or inflammation. Vitamin B1 deficiency has been implicated in myopathy as well. Thiamin (vitamin B1) supplementation can also ease pain from shingles, migraine headaches and arthritis. Similarly, clinical indicators of pain associated with rheumatoid arthritis are inversely correlated with B6 levels. Riboflavin (vitamin B2) has also shown promise in reducing pain associated with inflammatory conditions and acts as a powerful agent in preventing migraine headaches. Since the B-complex vitamins work together, it is crucial to assess the functional status of each one.
Folic Acid & Migraines
A recent study showed that migraine headaches in children were significantly reduced when supplemented with folic acid. Magnesium supplementation has similar beneficial effects on the pain of pediatric migraine attacks.
Copper & Arthritis
Copper is necessary for the production of super oxide dismutase, which is a powerful anti-inflammatory enzyme. When administered to patients with rheumatoid arthritis, copper is effective in reducing inflammatory pain. Copper supplementation has also relieved patients of leg pain associated with sciatic neuritis.
Antioxidants & Inflammatory Pain
The link between oxidative stress and inflammation has been well established. A patient in an inflammatory state will likely experience more pain. Studies have shown that reactive oxygen species are produced during persistent pain, indicating an increased need for antioxidants. Specifically, cysteine may have an inhibitory role in inflammatory pain due to its potent antioxidant effects on tissues. Similar results have been demonstrated with other antioxidants such as selenium, vitamin e, vitamin c, glutathione and coenzyme Q10. Recent studies show that intracellular inflammatory response in white blood cells play an important role in the pathophysiology of chronic fatigue syndrome. Combined antioxidant therapy also reduces pain in patients with chronic pancreatitis and fibromyalgia. Since many antioxidants work synergistically, measure a single antioxidant may not provide an accurate picture of total antioxidant function in patients experiencing either chronic or acute pain.
Topics: micronutrient testing, Coenzyme Q10, Oleic Acid, Arthritis, Vitamin D, Carnitine, Magnesium, Choline, B Vitamins, Folic Acid, Copper, Antioxidants, Pain, Migraines, Fatigue, Myopathy, Fibromyalgia