SpectraCell Blog

Study suggests testosterone therapy in men not harmful to prostate...

Posted by SpectraCell Laboratories, Inc. on Fri, Mar 06, 2015 @ 11:04 AM

 

Recent finding suggests testosterone therapy in men not harmful to prostatetestosterone


In a recently published study, 1023 hypogonadal men who received testosterone therapy were monitored for an average of 5 years for prostate cancer. The authors concluded that “testosterone therapy in hypogonadal men does not increase the risk of prostate cancer” although the authors did explicitly note that there was not control group in this study of men not taking testosterone.

Similar conclusions were reported in a different review of a testosterone replacement therapy in men, although the effect of testosterone on cardiovascular disease and events was much less clear. Whether or not to treat men with testosterone remains equivocal, as highlighted in the clinical decisions case study listed below.
(Journal of Urology, January 2015)
(Therapeutic Advances in Drug Safety, October 2014)
(New England Journal of Medicine, November 2014)

LINK to ABSTRACT Incidence of prostate cancer in hypogonadal men receiving testosterone therapy: observations from 5-year median followup of 3 registries.
LINK to ABSTRACT
Adverse effects of testosterone replacement therapy: an update on the evidence and controversy. LINK to FREE FULL TEXT
LINK to CASE STUDY 
Clinical decisions. Testosterone-replacement therapy.

For more information or to get tested, please visit www.spectracell.com

 

Topics: SpectraCell, micronutrient, Hormones, Testosterone

Studies Show How Micronutrients can Help

Posted by SpectraCell Laboratories, Inc. on Thu, Apr 11, 2013 @ 03:04 PM

Vitamin D protects telomeres: a randomized, controlled trialTelomeres

Telomerase activity was measured before and after 37 people were given either placebo or about 2000IU of oral vitamin D supplements per day for 16 weeks.  Serum vitamin D levels for those taking the supplement increased almost 200%.  The telomerase activity increased over 19% as well, while the telomerase activity of those on placebo did not change. (International Journal of Obesity, June 2012)

LINK to ABSTRACT Increased telomerase activity and vitamin D supplementation in overweight African Americans.
LINK to FLYER ON NUTRIENT INTERACTIONS WITH TELOMERES

Vitamin C helps antidepressant drug work better
Vitamin C In this randomized, double-blind, placebo controlled trial, a group of patients with major depressive disorder (n=12) were given fluoxetine plus 1000mg of vitamin C daily and compared to a group (n=12) that were given fluoxetine plus placebo.  After six months, those receiving vitamin C in conjunction with fluoxetine showed a significant decrease in symptoms when evaluated using three different standardized depression rating systems compared to the placebo group. (Nutrition Journal, March 2013)

LINK to ABSTRACT Efficacy of vitamin C as an adjunct to fluoxetine therapy in pediatric major depressive disorder: a randomized, double-blind, placebo-controlled pilot study.
LINK to FREE FULL TEXT
LINK to FLYER ON NUTRIENT INTERACTIONS IN DEPRESSION

Serine improves ADHD symptoms
serine resized 600In this randomized, double-blind trial, 36 children diagnosed with ADHD received either 200mg of phosphatidylserine or placebo daily for two months.  Those receiving phosphatidylserine showed improved memory, attention and control of impulses compared to placebo.  Serine’s key role in psychiatric and neurological health has been gaining attention from studies such as this.  The authors concluded that phosphatidylserine “may be a safe and natural nutritional strategy for improving mental performance.”
(Journal of Human Nutrition and Dietetics, March 2013)

LINK to ABSTRACT The effect of phosphatidylserine administration on memory and symptoms of attention-deficit hyperactivity disorder: a randomised, double-blind, placebo-controlled clinical trial.
LINK to FLYER ON NUTRIENT INTERACTIONS IN ADHD

Are micronutrients underrated when it comes to pregnancy chances in assisted reproduction?
pregnancy resized 600Several recent studies are suggesting that micronutrient status prior to and during pregnancy should get more attention.  One study showed that low blood values of B vitamins and high homocysteine in mid pregnancy reduced fetal growth rates.  Another study showed that low homocysteine, determined by B vitamin status, was linked to a better chance of pregnancy in women undergoing assisted reproduction.  Yet another study showed that subfertile women undergoing ovulation induction who were taking a multi-micronutrient vitamin were more likely to get pregnant than women who took only a folic acid supplement.  Finally, a recently published review demonstrates how increasing a woman’s ability to fight oxidative stress increases her chances of successful pregnancy via assisted reproduction.
(Maternal of Child Nutrition, April 2013)
(Journal of Assisted Reproduction and Genetics, April 2012)
(Reproductive Biomedicine Online, January 2012)
(Reproductive Biology and Endocrinology, June 2012)

LINK to ABSTRACT Folate, Vitamin B12, Vitamin B6 and homocysteine: impact on pregnancy outcome.
LINK to ABSTRACT
The association between homocysteine in the follicular fluid with embryo quality and pregnancy rate in assisted reproductive techniques.
LINK to ABSTRACT Prospective randomized trial of multiple micronutrients in subfertile women undergoing ovulation induction: a pilot study.
LINK to ABSTRACT The effects of oxidative stress on female reproduction: a review.
LINK to FREE FULL TEXT
LINK to FLYER ON NUTRIENT INTERACTIONS IN FEMALE FERTILITY

Study sheds light on CoQ10’s role in healthy spermsperm resized 600
Sixty infertile men were given 200mg of CoQ10 or placebo for 3 months.  CoQ10 lowered oxidative stress in semen (measured by isoprostanes and superoxide dismutase activity) and improved sperm function significantly. (Andrologia, January 2013)

LINK to ABSTRACT Effect of Coenzyme Q10 supplementation on antioxidant enzymes activity and oxidative stress of seminal plasma: a double-blind randomised clinical trial.

 

For more information on micronutrients and telomeres CLICK HERE

 

Topics: SpectraCell, serine, micronutrients, Coenzyme Q10, Antidepressants, Vitamin D, Vitamin C, Telomere testing, telomere, deficiency, micronutrient test, ADHD, Nutritional Deficiency, Heart Health, Nutrient, telomere test, Hormones, Aging, Reproductive Health, infertility, Testosterone, Women's Health

Nutrient Correlation Chart on Testosterone

Posted by SpectraCell Laboratories, Inc. on Thu, Apr 04, 2013 @ 02:39 PM

Folate Deficiency reduces circulating testosterone; Evidence suggests testosterone may Nutrient Correlation chart on Testosteroneregulate folate metabolism.1,2,3

Vitamin B6 Regulates sex hormones; Vitamin B6 reduces prolactin which stimulates hypothalamus to increase testosterone; B6 also a cofactor for dopamine synthesis which influences testosterone levels.4,5,6,7

Vitamin D Actually a hormone, vitamin D regulates the synthesis of testosterone; Supplementation can significantly increase total, free and bioactive testosterone levels. 8,9,10,11,12

Vitamin K Deficiency reduces testosterone production because the rate-limiting enzyme for testosterone synthesis (Cyp11a) is vitamin K dependent. 13,14,15

Vitamin E Long term administration of some forms of vitamin E may reduce testosterone levels.16,17

Vitamin C Studies suggest it protects prostate from testosterone induced tumors.18,19,20

Carnitine Boosts dopamine, which is directly related to testosterone levels; May prevent testosterone decline after intense physical stress.21,22,23,24

Magnesium Makes testosterone more biologically active in the body; Raises free and total testosterone levels in men.25,26,27

Zinc Deficiency lowers testosterone levels; Inhibits prolactin secretion (testosterone
inhibiting hormone); Supplementation increases testosterone depending on baseline levels.28,29,30,31

Click here to download your copy of the Nutrient Correlation chart on Testosterone

 

Topics: SpectraCell, zinc, folate, Vitamin D, Carnitine, Magnesium, Vitamin C, Vitamin E, Vitamin B6, Vitamin K, Vitamins, Nutrient, Hormones, Testosterone

SpectraCell's Clinical Updates - Volume 6, Issue 5

Posted by SpectraCell Laboratories, Inc. on Thu, May 31, 2012 @ 03:57 PM

Parkinson's DiseaseCLINICAL UPDATE - COQ10 A NEW BIOMARKER FOR PARKINSON'S DISEASE?
In this study, 22 patients with Parkinson’s Disease were compared to 88 age-matched controls that did not have Parkinson’s.  Functional levels of several antioxidants – coenzyme Q10, glutathione, selenium, vitamin E and lipoic acid – were measured using SpectraCell’s micronutrient testing.  A deficiency of CoQ10 occurred in 32% of Parkinson’s patients while only 8% of controls were deficient in coQ10.  Interestingly, this was not true for any other antioxidants, leaving authors to conclude that measuring coQ10 status could determine which Parkinson’s patients would benefit from coQ10 supplements, which has proven to slow the progression of Parkinson’s in various clinical trials. (Journal of Neurological Science, April 2012; Cochrane Database of Systematic Reviews, December 2011)

LINK to ABSTRACT Coenzyme Q10 deficiency in patients with Parkinson's disease.
LINK to ABSTRACT Coenzyme Q10 for Parkinson's disease.

Vitamin D and TestosteroneCLINICAL UPDATE - LOW VITAMIN D AND TESTOSTERONE IS A DEADLY COMBINATION
Testosterone and vitamin D was measured in over 2000 men. Those with a deficiency in both vitamin D and testosterone were more than twice as likely to have a fatal cardiovascular event and over 1 ½ times as likely to have a fatal event that was non- cardiovascular related. (Clinical Endocrinology, February 2012)

LINK to ABSTRACT Combination of low free testosterone and low vitamin D predicts mortality in older men referred for coronary angiography.

DepressionCLINICAL UPDATE - SMALL CHANGES IN OMEGA 3 INDEX = BIG CHANGES IN DEPRESSION RATES
Omega 3 index and fatty acids were measured in 150 adolescents that had been hospitalized for depression and compared to 161 controls.  For a 1% increase in the omega 3 index, teenagers were 28% less likely to have severe depression.   The omega 3 index is a measure of eicosapentaenoic acid (EPA) and docosahexanoeic acid (DHA) in red blood cells, which is correlates to fatty acid content in other tissues as well. (Prostaglandins, Leukotrienes and Essential Fatty Acids, April 2012)

LINK to ABSTRACT Red blood cell fatty acids are associated with depression in a case-control study of adolescents.

Choline and OffspringCLINICAL UPDATE - CHOLINE STATUS OF MOM AFFECTS HORMONE LEVELS IN OFFSPRING
Pregnant women were given either 930 or 480 mg/day of choline in their third trimester.  After twelve weeks, the group with higher choline intake had babies with less cortisol in their blood, possibly to due improved methylation of DNA in the placenta, which was also measured.  The authors concluded that maternal choline intake affects genes in the offspring that regulate cortisol production. (Federation of American Societies for Experimental Biology, May 2012)

LINK to ABSTRACT Maternal choline intake alters the epigenetic state of fetal cortisol-regulating genes in humans.

Pain and ShinglesCLINICAL UPDATE - INTRAVENOUS VITAMIN C REDUCES SHINGLES PAIN
In this study, 16 practioners gave vitamin C intravenously to 67 patients with symptomatic herpes zoster pain.  The dosage was 7.5 grams per 50 mL administered for two weeks.  Pain and skin eruptions associated with the shingles (herpes zoster) virus were significantly reduced for up to 12 weeks following injections. (Medical Science Monitor, April 2012)

LINK to ABSTRACT Intravenous Vitamin C in the treatment of shingles: Results of a multicenter prospective cohort study.
 
Trans FatsCLINICAL UPDATE - TRANS FATS LINKED TO AGGRESSION
Dietary intake of trans fat was estimated (via dietary survey) on 945 men and women and each rated their irritability and aggressive behaviours with a standardized test.  The authors of the study concluded that ‘this study provides the first evidence linking dietary trans fatty acids with behavioural irritability and aggression.” (PLoS One, 2012)

LINK to ABSTRACT Trans fat consumption and aggression.
LINK to FREE FULL TEXT

Browse our archive of all past clinical updates from the past 6 years!



Topics: Coenzyme Q10, Vitamin D, Choline, Vitamin C, Omega 3 Fatty Acid, Depression, Aggression, Hormones, Testosterone, Shingles, Trans Fats, Parkinsons disease