SpectraCell Blog

Theories, Research and Treatment with Vitamins and Antioxidants

Posted by SpectraCell Laboratories, Inc. on Thu, Mar 07, 2013 @ 09:31 AM

New theory on how vitamins work gains attention

A group of researchers in Europe proposed a new theory on how vitamins work in the body,vitamins displacing the former accepted view that vitamin molecules work directly on cells in the body. Their research, which used radiation and electron pulse technology, led them to conclude that antioxidant vitamins emit dissolved electrons that quench free radicals. They concluded that the well-known vitamin effects are attributed to “vitamin free radicals rather than the vitamin molecules per se, as generally accepted.”(Nutrition, January 2013)

Link to Abstract Vitamin-induced intracellular electrons are the mechanism for their well-known beneficial effects: A review.

Treatment resistant depression responds to folate therapy

Two randomized, double-blind trials were conducted in which depression, treatmentdepression patients who had a partial or no response to a SSRI (selective serotonin reuptake inhibitors) were given l-methylfolate for 60 days. In the first trial, the dosage of folate was 7.5mg/day for 30 days, then 15mg/day for 30 days. In the second trial, the dosage of folate was 15mg/day for 60 days. Patients in the second trial showed significantly greater efficacy of SSRI drugs (lower depression scores and significantly decreased symptom severity) compared to the first trial (where the dosage of folate was lower) and compared to placebo. (American Journal of Psychiatry, December 2012)

LINK to ABSTRACT  (L)-methylfolate as adjunctive therapy for SSRI-resistant major depression: results of two randomized, double-blind, parallel-sequential trial.
LINK to FLYER on NUTRIENT INTERACTIONS IN DEPRESSION

Antioxidant therapy benefits both anxiety and depression

Blood levels of the antioxidant (specifically, vitamins A, C and E) were measured in eighty patients ofantioxidant a psychiatric hospital that were diagnosed with stress-induced generalized anxiety disorder and depression. Supplements of each vitamin were given for six weeks and blood levels of each vitamin were measured again. After six weeks, blood levels of vitamin A and C had increased and there was a “significant reduction in anxiety and depression scores of patients.”(Indian Journal of Psychiatry, July2012)

LINK to ABSTRACT Role of antioxidants in generalised anxiety disorder and depression. 
LINK to FREE FULL TEXT
LINK to FLYER on NUTRIENT INTERACTIONS IN ANXIETY
LINK to FLYER on NUTRIENT INTERACTIONS IN DEPRESSION

Is B12 the magic bullet for hepatitis?

This paper concludes that B12 is particularly beneficial for hepatitis C viral therapy. Specifically, adding Vitamin B12vitamin B12 (5mg given intramuscularly every 4 weeks) to the conventional therapy of pegylated interferon plus ribavirin improved treatment response after 3 months. This confirms earlier research that shows vitamin B12 ca inhibit the hepatitis C virus in vitro.(Expert Review of Anti-Infective Therapy, November 2012)

LINK to ABSTRACT Vitamins? The magic bullet against hepatitis C.
LINK to FREE FULL TEXT

Vitamin D amplifies progesterone's neuroprotective effect after traumatic brain injury

Both progesterone and vitamin D have demonstrated neuroprotective effects on the brain after abrain injury traumatic injury in past studies, so a group of researchers sought to evaluate the effect of combining them. This randomized clinical trial compared progesterone treatment alone and combined with vitamin D to a placebo group and found that the “recovery rate of patients with severe brain trauma in the group receiving progesterone and vitamin D together was significantly higher than that of progesterone [only] group, which was in turn higher than that of placebo group.”(Advanced Biomedical Research, 2012)

LINK to ABSTRACT Comparison of the administration of progesterone versus progesterone and vitamin D in improvement of outcomes in patients with traumatic brain injury: A randomized clinical trial with placebo group.

Vitamin C help patients recover from hearing loss

72 patients with sudden hearing loss of unknown cause participated in this study. 36 patients served hearing lossas a control group that received steroid treatment for 15 days and 36 patients received the same steroid treatment plus high dose vitamin C intravenously daily for 10 days. Auditory evaluations were administered and the recovery rate of the group receiving vitamin C was more than twice that of the control group. (European Archives of Oto-rhino-laryngology, December 2012) 

LINK to ABSTRACT Effect of high dose intravenous vitamin C on idiopathic sudden sensorineural hearing loss: a prospective single-blind randomized controlled trial.

Mechanism behind serine's role for proper brain function is uncovered

Serine is a crucial amino acid needed to form proper synapses in the brain. It acts as abrain neurotransmitter and regulates NMDA(N-methyl-D-aspartate) receptors in the brain, which regulate mood and sleep, explaining its role in psychiatric and neurological disease. A recent study showed that serine supplementation could reverse oxidative stress-induced deficits in cognitive function.(Current Opinion in Clinical Nutrition and Metbolic Care, January 2013), (Aging Cell, April 2012), (Journal of Biological Chemistry, June 2012), (Biochemical Journal, 2003)

LINK to ABSTRACT D-Serine: physiology and pathology.
LINK to ABSTRACT Reversal of age-related oxidative stress prevents hippocampal synaptic plasticity deficits by protecting D-serine-dependent NMDA receptor activation.
LINK to ABSTRACT Resurgence of serine: an often neglected but indispensable amino acid.
LINK to ABSTRACT L-serine in disease and development. 
LINK to FREE FULL TEXT

For more educational resources visit our Clinical Education Center  

 

Topics: SpectraCell, Antidepressants, Autoimmunity, autoimmune diseases, folate, Vitamin D, Vitamin C, B Vitamins, Folic Acid, Antioxidants, Vitamin B12, immune system, Vitamins, Fertility, Case Study, Hearing, Depression, Brain, Hepatitis, anxiety

SpectraCell's Nutritional Correlation Chart on Autism

Posted by SpectraCell Laboratories, Inc. on Wed, Feb 06, 2013 @ 01:54 PM

Autism Nutritional WheelVitamin D - High dose vitamin D therapy reversed autistic behaviors in severely deficient children; Maternal vitamin D deficiency may predispose children to autism.3,4,5

Vitamin A - One cause of autism may be a defect in a retinoid receptor protein (G-alpha protein) which is critical for language processing, attention and sensory perception; Evidence suggests natural vitamin A fixes this protein defect in autistics.1,2

Folate - Oral folate therapy can resolve symptoms of autism in some cases, particularly in autistics with genes that impair folate dependent enzymes.31,32,33

Glutamine - Blood levels of this amino acid which acts as a neurotransmitter are particularly low in autistics. Glutamine also helps prevent leaky gut syndrome, which can exacerbate autistic symptoms.28,29,30

Vitamin C - Improved symptom severity and sensory motor scores in autistic patients possibly due to interaction with dopamine synthesis; Vitamin C also has a strong sparing effect on glutathione.26,27

Glutathione & Cysteine -  Commonly deficient in autistic patients, lack of these antioxidants impair detoxification and methylation processes; Low levels linked to neurological symptoms in autism which is often considered an oxidative stress disorder.21,22,23,24,25

Vitamin B1 - Deficiency linked to delayed language development; Supplementation may benefit autistic patients.19,20

Vitamin B12 - Low B12 impairs methylation (detoxification) which causes the neurological damage responsible for many autistic symptoms; Deficiency of B12 can cause optic neuropathy and vision loss in autistics; B12 raises cysteine and glutathione levels.16,17,18

Vitamin B6 - Cofactor the neurotransmitters serotonin and dopamine; Conversion of B6 to its active form is compromised in many autistics; Supplementation trials with B6 resulted in better eye contact, speech and fewer self-stimulatory behavior in autistics; Some consider B6 in combination with magnesium to be a breakthrough treatment for autism.14,15

Magnesium - Cofactor for the neurotransmitters that affect social reactions and emotion; Autistics have low levels; Improves effectiveness of B6 therapy.11,12,13

Zinc - Eliminates toxic mercury from brain tissue; Zinc/ copper ratio is particularly low in autistic kids; Low zinc impairs  the protein (called metallothionein) that removes heavy metals from the body.8,9,10

Carnitine - Transports fatty acids into cells; Low carnitine (common in autism) impairs the ability to use fatty acids for learning and social development.6,7

 For a copy of Spectracell's Nutrition Correlation chart on Autism click here

Topics: micronutrients, micronutrient testing, Cysteine, Antidepressants, zinc, folate, Vitamin D, Carnitine, Magnesium, Vitamin C, Vitamin A, Vitamin B6, B Vitamins, Antioxidants, diagnostic tools, supplements, autism, Vitamins, DNA, deficiencies, health, deficiency, Depression, Glutamine, Neurology, Glutathione, Diet, Minerals, Digestion, Brain, Nervous System, Neurotransmitters, Aggression, Stress, Vitamin B1, degenerative illness, micronutrient test

Vitamins, minerals and antioxidants can help!

Posted by SpectraCell Laboratories, Inc. on Thu, Jan 10, 2013 @ 01:20 PM

Is carnitine the answer for male infertility?male, infertility
A group of men (n=96) who had been diagnosed as infertile for at least 18 months were given the following nutritional formulation daily for four months: L-carnitine, acetyl-L-carnitine, fructose, citric acid, selenium, coenzyme Q10, zinc, vitamin C, vitamin B12 and folic acid (see abstract for exact dosages).  At the end of the study, sperm motility improved and 16 of the patients had achieved pregnancy.  The authors concluded that carnitine may be the key component of the supplement cocktail for improving sperm quality. (Italian Archives of Urology and Andrology, September 2012)

LINK to ABSTRACT Prospective open-label study on the efficacy and tolerability of a combination of nutritional supplements in primary infertile patients with idiopathic astenoteratozoospermia.

 

Vitamin D helps leg ulcers heal
In this double-blind, placebo controlled trial, 26 patients Vitamins, Vitamin Dwith leg ulcers were given either placebo or 50,000 IU vitamin D weekly for two months.  Leg ulcer size, blood levels of vitamin D and pain was measured before and after the two month trial.  In the vitamin D group, leg ulcers were reduced in size by 28% while the placebo group had only a 9% reduction in ulcer size. The authors stated “there was a trend toward better healing in those with vitamin D reposition.” (Journal of Brazilian College of Surgeons, October 2012)

LINK to ABSTRACT Vitamin D and skin repair: a prospective, double-blind and placebo controlled study in the healing of leg ulcers.
LINK to FREE FULL TEXT

 

Complexity of methylation reactions gains insightmethyl donor, nutrients
This review emphasizes how methyl donor nutrients such as choline, folic acid and methionine interact and how consumption (via supplement or food) of one can have sparing effect s on another – such as choline’s  sparing effect on methionine, for example. (Current Opinion in Clinical Nutrition and Metabolic Care, January 2013)

LINK to ABSTRACT The nutritional burden of methylation reactions.
LINK to FLYER on NUTRIENT INTERACTIONS in METHYLATION

For more journal articles by disease or nutrient please click here

 

Topics: SpectraCell, serine, micronutrients, Coenzyme Q10, Oleic Acid, Cysteine, autoimmune diseases, zinc, Vitamin D, Carnitine, Magnesium, Choline, Vitamin C, Vitamin E, Vitamin A, Selenium, Vitamin B6, B Vitamins, Folic Acid, Antioxidants, lipoprotein particle profile, Omega 3 Fatty Acid, diagnostic tools, vitamin, wellness, pregnancy, Serum, Vitamin K, Vitamin B12, supplements, Multivitamins, Nutrition, diabetes, immune system, E-zinc, N-acetylcysteine, DNA, Calcium, Fertility, Lipoic Acid, deficiencies, health, Case Study, Omega 3s, Depression, Glutamine, Minerals, Neurotransmitters, Stress, Vitamin B1, micronutrient test, Vitamin B5, Vitamin B2, Nutritional Deficiency, Vitamin B3, cardiovascular disease, Hormones, Reproductive Health, Chromium, Manganese, Muscle recovery, Erectile Dysfunction, infertility, Niacin, Prostate, Energy, Methylation, Carbohydrate Metabolism

The Importance of Vitamins

Posted by SpectraCell Laboratories, Inc. on Fri, Jan 04, 2013 @ 01:12 PM

New study says multivitamins just don’t cut it when it comes to preventing heart diseaseVitamins, multi-vitamins

In the landmark Physician’s Health Study II, authors concluded that taking a multivitamin for over a decade did nothing to prevent cardiovascular events such as myocardial infarction or stroke. The study monitored 14,641 male doctors for over eleven years who took either a daily multivitamin or placebo and no differences in cardiovascular events or mortality was found between the two groups.  Since evidence linking deficiencies to heart disease is strong (see vitamin D study below on 45,000 patients), some conclude that a multivitamin is simply not effective in correcting deficiencies and that targeted supplementation for the individual is a better approach. (Journal of the American Medical Association, November 2012)
(American Journal of Cardiology, October 2010)

Link to ABSTRACT Multivitamins in the prevention of cardiovascular disease in men: the Physicians' Health Study II randomized controlled trial.

Link to ABSTRACT Relation of vitamin D deficiency to cardiovascular risk factors, disease status, and incident events in a general healthcare population.

Vitamin C reduces fatigue and perception of effort after exercise

Vitamins, vitamin cIn this interesting study on twenty obese adults, each were given either 500 mg of vitamin C or placebo daily for four weeks.  Their diet was strictly controlled for vitamin C content and their heart rates and fatigue scores as well as subjective perceptions of exertion were measured after exercise.  Those taking vitamin C had lower fatigue scores and those on placebo had higher fatigue scores. Heart rates and “ratings of perceived exertion” were also improved in the vitamin C group. (Nutrition, January 2013)   

Link to ABSTRACT Vitamin C status and perception of effort during exercise in obese adults adhering to a calorie-reduced diet.

For more articles and information, click here for the complete library on clinical updates.

Topics: Coenzyme Q10, zinc, Vitamin D, Vitamin C, Vitamin E, Vitamin A, Vitamin B6, B Vitamins, Folic Acid, Copper, diagnostic tools, Heart Disease, vitamin, Vitamin K, Vitamin B12, supplements, Multivitamins, E-zinc, Vitamins, deficiencies, Heart Attack, Diet, Minerals, Vitamin B1, micronutrient test, Vitamin B5, High Blood Pressure, Vitamin B2, Heart Health, Vitamin B3, Aging, Stroke

SpectraCell's Clinical Updates - volume 6 Issue 11

Posted by Char Perez on Thu, Dec 13, 2012 @ 11:18 AM

CLINICAL UPDATE – Nutritional status of mom has major implications foNutrition, Vitamins, vitamin B12r baby 

Three recent studies emphasize the fallacy of the paradigm “baby gets what he needs at the expense of the mother.” In one study done in the Netherlands, researchers evaluated over 3200 mothers for blood folate levels and their children at three years of age for behavioural and emotional problems. Although the implications of low folate status of the mother on neurological development is well established, this study reported that low folate status of the mother is linked with a “higher risk of emotional problems in the offspring.”  An unrelated study in India found a similar result with vitamin B12 and heart function. Cord blood of mothers was compared to the cardiac function of their babies. “Children born to mothers with a lower vitamin B12 status have a reduced cardiac sympathetic activity.”  Finally, a review of studies done between 1999 and 2011 concluded that vitamin D deficiency of mom is linked to gestational diabetes. (American Journal of Clinical Nutrition, June 2012),(Maternal and Child Nutrition, May 2012),(Journal of Obstetric,  Gynecologic and Neonatal Nursing, May 2012)

Link to Abstract Maternal folate status in early pregnancy and child emotional and behavioral problems: the Generation R Study.

Link to Abstract Low maternal vitamin B12 status during pregnancy is associated with reduced heart rate variability indices in young children.

Link to Abstract Maternal vitamin d status as a critical determinant in gestational diabetes.

CLINICAL UPDATE - E Zinc deficiency common in diabetics                                                        

Diabetes, E-zinc, serumSerum and intracellular levels were measured in 75 type I and II diabetics and compared to 75 age matched controls.  Zinc levels were significantly lower in diabetic patients.  Authors of the study reported that in vivo and in vitro studies indicate that zinc promotes insulin signalling and supplementation may be a potential treatment in zinc-deficient diabetics. (Journal of Nutritional Biochemistry, November 2012)   

Link to Abstract Disturbed zinc homeostasis in diabetic patients by in vitro and in vivo analysis of insulinomimetic activity of zinc.

CLINICAL UPDATE – N-acetylcysteine lowers irritability in autistic kids

In this randomized clinical trial on 33 autistic children ages three to ten years old, a dose of 900mg N-acetylcysteine was given twice daily for 12 weeks.   At each 4 week interval, a standardized test was given to measure irritability and behaviour on each child.  After three months, those receiving the high-dose N-acetylcysteine had significant improvements on their irritability compared to the placebo group. (Biological Psychiatry, June 2012)      

Link to Abstract  A randomized controlled pilot trial of oral N-acetylcysteine in children with autism.

CLINICAL UPDATE – Vitamin D trial shows it can reduce body fat


vitamin D
In a double-blind, randomized, placebo-controlled trial, 77 people were given either 25mμg of vitamin D or placebo for 12 weeks. Researchers concluded that “supplementation with vitamin D3 caused a statistically significant decrease in body fat mass.”  Specifically, the vitamin D group lost six pounds while the placebo group lost an average of only one pound. (Nutrition Journal, May 2012)             

Link to Abstract A 12-week double-blind randomized clinical trial of vitamin D3 supplementation on body fat mass in healthy overweight and obese women.

Link to Full Text 

CLINICAL UPDATE – Vitamin K reduces diabetes risk

diabetes, vitaminsDietary intake of phylloquinone (a form of vitamin K) was assessed in over a thousand men and women.  Those with increased intake of vitamin K hahave lower rates of diabetes.  As a follow up to the study, the people who increased their dietary vitamin K during the follow-up had 51% reduced risk of diabetes. (American Journal of Clinical Nutrition, November 2012)                                           

Link to Abstract Dietary phylloquinone intake and risk of type 2 diabetes in elderly subjects at high risk of cardiovascular disease.

CLINICAL UPDATE – Vitamin E kills cancer cells

Cancer Cells Immune SystemThe alpha, delta and gamma tocotrienol forms of vitamin E were evaluated on leukemic cancer cells.  The delta tocotrienol form of vitamin E, which was the most potent in killing cancer cells, changed the DNA of the cancerous cells in such a way that it induced the cancerous cells to undergo apoptosis (cell death). (Microscopy and Microanalysis, June 2012)      

 

Link to Abstract Delta- and gamma-tocotrienols induce classical ultrastructural apoptotic changes in human T lymphoblastic leukemic cells.                               

To further enhance your knowledge of nutritional considerations for improved clinical patient care, click here for our webinar series library.       

Topics: cancer cells, autoimmune diseases, zinc, Vitamin D, Vitamin C, Vitamin E, vitamin, nutrition testing, wellness, pregnancy, Serum, Vitamin K, Vitamin B12, supplements, Multivitamins, Chronic Disease, Weight Loss, Nutrition, diabetes, immune system, expecting mothers, cord blood, cardiac, early pregnancy, E-zinc, N-acetylcysteine, autism, body fat, Vitamins, DNA, overweight, breast cancer, leukemia, Women's Health

SpectraCell's Nutritional Correlation Chart on Diabetes

Posted by Char Perez on Mon, Dec 03, 2012 @ 10:23 AM

Micronutrients such as niacin, magnesium, calcium, zinc, carnitine, inositol, alpha-lipoic acid, as well as vitamins E, B6 and D all play an important role in the prevention and treatment of diabetes.

Though diabetes is a serious disease - with the right treatment - living a longer, healthier life can be made easier.

THE ROLE OF MICRONUTRIENTS IN DIABETIC HEALTH

Vitamin E - Confers protection against diabetes by protecting pancreatic B-cells from nutrition reference chart for diabetesoxidativestress induced damage; May prevent progression of type I diabetes.

Vitamin D - Lowers risk of type I and 2 diabetes; Suppresses inflammation of pancreatic B-cells. Vitamin D receptor gene linked to diabetes.

Vitamin B3 - Preserves B-cell function in type I diabetics; Part of GTF (glucose tolerance factor) which facilitates insulin binding.

Vitamin B12 - Deficiency common in diabetics because metformin depletes B12.

Chromium - Helps insulin attach to cell's receptors increasing glucose uptake into cell; Deficiency can cause insulin resistance; Supplementation trials show dose-dependent benefits for type II diabetics.

Biotin - Stimulates glucose-induced insulin secretion in pancreatic B-cells; High dose biotin can improve glycemic control in diabetics.

Magnesium - Deficiency reduces insulin sensitivity; Low magnesium exacerbates foot ulcers in diabetics.

Zinc - Needed in the synthesis, storage and secretion of insulin; Protects pancreatic B-cells from damage; Affects the expression of genes linked to diabetes.

Lipoic Acid - Enhances glucose uptake in skeletal muscle tissue; Improves glucose tolerance in type 2 diabetics; very effective treatment for diabetic neuropathy.

Glutathione & Cysteine - Glutathione-containing enzymes protect B-cells which are particularly sensitive to oxidative stress; Type 2 diabetics have abnormal antioxidant status; Supplementation with the glutathione precursor cysteine restores antioxidant status.

Coenzyme Q10 - Protects kidney from diabetes related damage; Improves glycemic control in type 2 diabetics.

Glutamine - Stimulates a hormone called GLP-I (glucagon-like peptide I) that regulates insulin secretion after meals; Improves insulin signaling and sensitivity.

Carnitine - Reduces and even prevents pain from diabetic neuropathy; Improves insulin sensitivity by increasing glucose uptake and storage.

Inositol - Evidence suggests that inositol may be effective in treating diabetic neuropathy.

Vitamin C - Lowers glycolysated hemoglobin (HbA1c) and fasting and post-meal glucose levels and in type 2 diabetics.  

To assess a copy of the flyer which illustrates the interaction of micronutrients and their effect on patients' diabetes click here:  http://www.spectracell.com/media/disease-wheel-diabetes.pdf

Topics: SpectraCell, micronutrient testing, Coenzyme Q10, Cysteine, zinc, Vitamin D, Carnitine, Magnesium, Vitamin C, Vitamin E, B Vitamins, Vitamin B12, diabetes, immune system, Lipoic Acid, biotin, inositol, deficiency, Glutamine, Glutathione, micronutrient test, Wound Healing, Vitamin B3, reference chart, Chromium, Insulin

SpectraCell's Clinical Updates - Volume 6, Issue 7

Posted by SpectraCell Laboratories, Inc. on Thu, Aug 09, 2012 @ 10:37 AM

Omega 3sCLINICAL UPDATE - Omega 3s Can Replace Ibuprofen for PMS Pain
In this trial, a group of women were given either placebo or omega3 fatty acids for three months, followed by three months of the opposite regimen.  Symptoms of PMS, especially pain, were monitored. After 3 months of treatment, women who took the omega 3 capsules every day decreased their ibuprofen usage by 19% (first group) and by 53% (second group). (International Journal of Gynaecology and Obstetrics, April 2012)

LINK to ABSTRACT  Effect of omega-3 fatty acids on intensity of primary dysmenorrhea

AsthmaticsCLINICAL UPDATE - Carnitine Supplements Improve Lung Function in Asthmatics
A recent placebo-controlled study compared 50 children with asthma to 50 healthy controls and found that not only were levels of the amino acid carnitine lower in those with asthma, but supplementation with 350mg of L-carnitine daily for six months significantly improved lung function is those with asthma.   Researchers noted that carnitine’s primary role in transporting fatty acids into the mitochondria may explain its benefit to those with asthma – carnitine also transports fatty acids to lung membrane surfaces ensuring they are lubricated, explaining a mechanism by which carnitine improves pulmonary function. (Journal of Allergy, 2012)

LINK to ABSTRACT L-carnitine improves the asthma control in children with moderate persistent asthma.
LINK to FREE FULL TEXT
LINK to FLYER on NUTRIENT INTERACTIONS OF ASTHMA

DiabetesCLINICAL UPDATE - Vitamin C Benefits Diabetics on Metformin
Seventy patients with type II diabetes were given either placebo or 500mg vitamin C twice a day.  All patients were taking metformin as well. After twelve weeks, measures of blood sugar control (fasting blood sugar, post-meal blood glucose and HbA1c levels) were all improved in the vitamin C group only. (Advances in Pharmalogical Sciences, 2011)

LINK to ABSTRACT Supplementation of vitamin C reduces blood glucose and improves glycosylated hemoglobin in type 2 diabetes mellitus: a randomized, double-blind study.
LINK to FREE FULL TEXT

Brain InjuryCLINICAL UPDATE - Zinc: A New Role for Traumatic Brain Injury
In this review, the protective role of zinc against traumatic brain injury is elucidated.  The authors stat that human clinical data “suggest that zinc may increase resilience” and can be used “to improve cognitive and behavioural deficits associated with brain injury.” (Nutrition Reviews, July 2012)

LINK to ABSTRACT Improving treatments and outcomes: an emerging role for zinc in traumatic brain injury.

FertilityCLINICAL UPDATE - Vitamin E Increases Sperm Count
106 infertile men were included in this trial  – 64 were infertile due to low sperm count and 42 were infertile due to poor sperm motility.  They were divided into two groups – both groups received pharmaceutical therapy for fertility but only one group was simultaneously treated with a natural form of vitamin E.  Sperm count and motility improved more dramatically in the vitamin E treated group.  In fact, only five natural pregnancies occurred in the non-vitamin E group, while 15 natural pregnancies occurred in the vitamin E treated group.  In an unrelated trial, vitamin E was co-administered with fertility drugs to a group of women and compared to fertility drug treated women without vitamin E.  Although those treated with vitamin E did not have statistically higher rates of pregnancy, the women given vitamin E did show significantly improved endometrial thickness, which would facilitate future pregnancy. (Natural Journal of Andrology, May 2012; Journal of Assisted Reproduction and Genetics, April 2012)

LINK to ABSTRACT Efficacy of natural vitamin E on oligospermia and athenospermia: a prospective multi-centered randomized controlled study of 106 cases.
LINK to ABSTRACT Vitamin E effect on controlled ovarian stimulation of unexplained infertile women.

Muscle MassCLINICAL UPDATE - A New Role for Omega 3s in Building Muscle Mass
A group of women (average age = 64 years old) were put on a strength training program for 90 days.  Some of the women were given fish oil supplements while others received no supplement. Measures of muscle strength were taken and those taking fish oil showed significantly higher muscle development.  Researchers hypothesized that this increase in muscle development during strength training is due to the role omega 3 fatty acids play in plasma membranes and muscle cell function. (American Journal of Clinical Nutrition, February 2012)

LINK to ABSTRACT Fish-oil supplementation enhances the effects of strength training in elderly women.

SerineCLINICAL UPDATE - High Dose Serine Improves Neuropathy: Case Report
One of the most common inherited neurological disorders, Charcot-Marie-Tooth disease affects approximately 1 in every 2500 people and is characterized by muscle wasting and peripheral neuropathy. In this case report, a male patient with polyneuropathy had a serine synthesis defect.  Deficiency in the amino acid serine often manifests neurologically and in this case, high-dose supplementation of serine improved his neuropathy symptoms. (Archives of Neurology, March 2012)

LINK to ABSTRACT A Serine Synthesis Defect Presenting With a Charcot-Marie-Tooth-Like Polyneuropathy.

Clicke HERE to browse our archived library of clinical updates

Topics: serine, zinc, Carnitine, Vitamin C, Vitamin E, diabetes, Fertility, PMS, Omega 3s, Asthma

NEW! SpectraCell's Asthma Quick Reference Chart

Posted by SpectraCell Laboratories, Inc. on Thu, Jul 26, 2012 @ 10:12 AM

Asthma WheelDuring last week's webinar, "Nutritional Considerations of Allergies & Asthma", we created and offered a copy of our new "Asthma Quick Reference Nutrient Chart".  This visual tool is an excellent resource to emphasize to your patients the many inter-related roles that nutrition plays in disease prevention and management.

View and/or download our flyer on Asthma HERE.

You can also view the rest of our library of quick reference nutrient charts HERE. Each chart is available as an individual handout and includes references posted on the reverse side. Our clients can order supplies by calling us at 800-227-5227 or visiting our Physician Access Center.


Topics: Coenzyme Q10, zinc, folate, Vitamin D, Carnitine, Magnesium, Choline, Vitamin C, Vitamin E, Vitamin A, Selenium, Vitamin B6

Nutritional Considerations of Pain

Posted by SpectraCell Laboratories, Inc. on Mon, Jul 23, 2012 @ 09:20 AM

PainBelow is a list of various nutrients that affect a person affected with body pain.

  • Cysteine - reduces pain caused by systemic inflammation due to its potent antioxidant properties.
  • Inositol - in animal studies, treatment with inositol induces antinociception (pain reduction).
  • Oleic Acid - this fatty acid is a precursor of oleamide, an analgesic that affects neurotransmitters such as dopamine, serotonin, acetylcholine and GABA (gamma amino butyric acid), all of which play a role in pain signaling.
  • Carnitine - deficiency of this amino acid may manifest as muscle weakness, pain (myalgia) or neuropathy. Supplementation reduces several types of chronic pain.
  • Magnesium - lowers pain by blocking NMDA receptors in spinal cord; effective in reducing post-operative pain.
  • Minerals:
    • Manganese - a cofactor for the potent antioxidant superoxide dismutase, which fights free radicals, a known source of pain.
    • Copper - supplementation can relieve arthritic pain.
    • Selenium - treatment with this mineral improves muscle pain in deficient patients.
    • Zinc & Calcium - research suggests both play a role in the transmission of pain signals through nerves.
  • Choline - activates specific receptors in brain and spine that lower acute pain.
  • Vitamin B1, B2, B6, B12 - these produce a dose dependent decrease in various kinds of pain (heat, pressure, chemical); increases sensitivity to pain meds; their effect is likely mediated through serotonergic neurotransmitters.
  • Vitamin D - deficiency often presents clinically as muscle or bone pain.
  • Lipoic Acid - very effective treatment for neuropathic pain.
  • Antioxidants - clinical trials show antioxidant therapy is an effective treatment for chronic pain
    • Vitamin E - reduces neuropathic pain
    • Vitamin C - can lower morphine consumption after surgery
    • Coenzyme Q10 - relieves statin-induced myopathy.

Download our 1-page flyer which illustrates the information above, HERE!

Topics: Coenzyme Q10, Oleic Acid, Cysteine, zinc, Vitamin D, Carnitine, Magnesium, Choline, Vitamin C, Vitamin E, Selenium, Vitamin B6, Copper, Antioxidants, Pain, Vitamin B12, Calcium, Lipoic Acid, inositol, Vitamin B1, Vitamin B2, Manganese

SpectraCell's Clinical Updates - Volume 6, Issue 5

Posted by SpectraCell Laboratories, Inc. on Thu, May 31, 2012 @ 03:57 PM

Parkinson's DiseaseCLINICAL UPDATE - COQ10 A NEW BIOMARKER FOR PARKINSON'S DISEASE?
In this study, 22 patients with Parkinson’s Disease were compared to 88 age-matched controls that did not have Parkinson’s.  Functional levels of several antioxidants – coenzyme Q10, glutathione, selenium, vitamin E and lipoic acid – were measured using SpectraCell’s micronutrient testing.  A deficiency of CoQ10 occurred in 32% of Parkinson’s patients while only 8% of controls were deficient in coQ10.  Interestingly, this was not true for any other antioxidants, leaving authors to conclude that measuring coQ10 status could determine which Parkinson’s patients would benefit from coQ10 supplements, which has proven to slow the progression of Parkinson’s in various clinical trials. (Journal of Neurological Science, April 2012; Cochrane Database of Systematic Reviews, December 2011)

LINK to ABSTRACT Coenzyme Q10 deficiency in patients with Parkinson's disease.
LINK to ABSTRACT Coenzyme Q10 for Parkinson's disease.

Vitamin D and TestosteroneCLINICAL UPDATE - LOW VITAMIN D AND TESTOSTERONE IS A DEADLY COMBINATION
Testosterone and vitamin D was measured in over 2000 men. Those with a deficiency in both vitamin D and testosterone were more than twice as likely to have a fatal cardiovascular event and over 1 ½ times as likely to have a fatal event that was non- cardiovascular related. (Clinical Endocrinology, February 2012)

LINK to ABSTRACT Combination of low free testosterone and low vitamin D predicts mortality in older men referred for coronary angiography.

DepressionCLINICAL UPDATE - SMALL CHANGES IN OMEGA 3 INDEX = BIG CHANGES IN DEPRESSION RATES
Omega 3 index and fatty acids were measured in 150 adolescents that had been hospitalized for depression and compared to 161 controls.  For a 1% increase in the omega 3 index, teenagers were 28% less likely to have severe depression.   The omega 3 index is a measure of eicosapentaenoic acid (EPA) and docosahexanoeic acid (DHA) in red blood cells, which is correlates to fatty acid content in other tissues as well. (Prostaglandins, Leukotrienes and Essential Fatty Acids, April 2012)

LINK to ABSTRACT Red blood cell fatty acids are associated with depression in a case-control study of adolescents.

Choline and OffspringCLINICAL UPDATE - CHOLINE STATUS OF MOM AFFECTS HORMONE LEVELS IN OFFSPRING
Pregnant women were given either 930 or 480 mg/day of choline in their third trimester.  After twelve weeks, the group with higher choline intake had babies with less cortisol in their blood, possibly to due improved methylation of DNA in the placenta, which was also measured.  The authors concluded that maternal choline intake affects genes in the offspring that regulate cortisol production. (Federation of American Societies for Experimental Biology, May 2012)

LINK to ABSTRACT Maternal choline intake alters the epigenetic state of fetal cortisol-regulating genes in humans.

Pain and ShinglesCLINICAL UPDATE - INTRAVENOUS VITAMIN C REDUCES SHINGLES PAIN
In this study, 16 practioners gave vitamin C intravenously to 67 patients with symptomatic herpes zoster pain.  The dosage was 7.5 grams per 50 mL administered for two weeks.  Pain and skin eruptions associated with the shingles (herpes zoster) virus were significantly reduced for up to 12 weeks following injections. (Medical Science Monitor, April 2012)

LINK to ABSTRACT Intravenous Vitamin C in the treatment of shingles: Results of a multicenter prospective cohort study.
 
Trans FatsCLINICAL UPDATE - TRANS FATS LINKED TO AGGRESSION
Dietary intake of trans fat was estimated (via dietary survey) on 945 men and women and each rated their irritability and aggressive behaviours with a standardized test.  The authors of the study concluded that ‘this study provides the first evidence linking dietary trans fatty acids with behavioural irritability and aggression.” (PLoS One, 2012)

LINK to ABSTRACT Trans fat consumption and aggression.
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Topics: Coenzyme Q10, Vitamin D, Choline, Vitamin C, Omega 3 Fatty Acid, Depression, Aggression, Hormones, Testosterone, Shingles, Trans Fats, Parkinsons disease